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Tropomyosin 4 Proteins (TPM4)

TPM4 encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Additionally we are shipping Tropomyosin 4 Antibodies (41) and Tropomyosin 4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPM4 7171 P67936
TPM4 326618 Q6IRU2
TPM4 24852 P09495
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Top Tropomyosin 4 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TPM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Tropomyosin 4 Proteins

  1. Human TPM4 Protein expressed in Escherichia coli (E. coli) - ABIN667406 : Lehman, Hatch, Korman, Rosol, Thomas, Maytum, Geeves, Van Eyk, Tobacman, Craig: Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. in Journal of molecular biology 2000 (PubMed)
    Show all 2 references for ABIN667406

  2. Human TPM4 Protein expressed in Human Cells - ABIN2006048 : Rostila, Puustinen, Toljamo, Vuopala, Lindström, Nyman, Oksa, Vehmas, Anttila: Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. in Lung cancer (Amsterdam, Netherlands) 2012 (PubMed)

More Proteins for Tropomyosin 4 (TPM4) Interaction Partners

Human Tropomyosin 4 (TPM4) interaction partners

  1. In addition to CLIC1 (show CLIC1 Proteins) and TPM1 (show TPM1 Proteins), which were the proteins initially discovered in a xenograft mouse model, CLIC4 (show CLIC4 Proteins), TPM2 (show TPM2 Proteins), TPM3 (show TPM3 Proteins), and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  2. Data indicate the upregulation of tropomyosin-4 in infiltrating ductal breast carcinomas (IDCAs) tissues, which may suggest its involvement in breast cancer development.

  3. Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 (show PRDX1 Proteins) with lung cancer.

  4. TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal remodelling proteins in early pregnancy

  5. Low TPM4 expression in the cytoplasm is associated with uterine cervix carcinogenesis.

  6. Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle.

Mouse (Murine) Tropomyosin 4 (TPM4) interaction partners

  1. Tm-4 is specifically enriched within and around osteoclast attachment structures, the sealing zone and podosomes.

  2. Tropomyosin 4 defines longitudinal filaments in mouse models of muscular dystrophy and nemaline myopathy.

  3. These results indicate that Tm-4 plays a role in regulating adhesion structures of osteoclasts, most likely by stabilizing the actin microfilaments present in podosomes and the sealing zone.

Pig (Porcine) Tropomyosin 4 (TPM4) interaction partners

  1. upregulation of tropomyosin 4 (TM4) mRNA is a relevant marker of dedifferentiation in vascular smooth muscle cells.

Zebrafish Tropomyosin 4 (TPM4) interaction partners

Tropomyosin 4 (TPM4) Protein Profile

Protein Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tropomyosin 4 Proteins (TPM4)

  • tropomyosin 4 (TPM4)
  • tropomyosin 4 (LOC100192321)
  • tropomyosin 4 (Tpm4)
  • tropomyosin 4a (tpm4a)
  • 2610528G24Rik protein
  • tpm4 protein
  • wu:fb06e07 protein
  • zgc:63909 protein
  • zgc:103436 protein

Protein level used designations for Tropomyosin 4 Proteins (TPM4)

tropomyosin 4 , tropomyosin alpha-4 chain , TM30p1 , tropomyosin-4 , TM-4 , tropomycin 4

GENE ID SPECIES
465115 Pan troglodytes
535277 Bos taurus
609879 Canis lupus familiaris
100192321 Taeniopygia guttata
7171 Homo sapiens
326618 Mus musculus
24852 Rattus norvegicus
397608 Sus scrofa
406437 Danio rerio
Selected quality suppliers for Tropomyosin 4 Proteins (TPM4)
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