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anti-Tryptophan Hydroxylase 2 (TPH2) Antibodies

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Additionally we are shipping Tryptophan Hydroxylase 2 Kits (18) and Tryptophan Hydroxylase 2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TPH2 121278 Q8IWU9
TPH2 216343 Q8CGV2
TPH2 317675 Q8CGU9
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Top anti-Tryptophan Hydroxylase 2 Antibodies at antibodies-online.com

Showing 10 out of 135 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TPH2 Antibody (Center) (ABIN653124) in 293 cell line lysates (35 µg/lane). TPH2 (arrow) was detected using the purified polyclonal antibody. TPH2 Antibody (Center) (ABIN653124) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Goat Un-conjugated EIA, IHC (p) AP23653PU-N TPH2 antibody staining of Paraffin Embedded Human Brain Stem at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB TPH2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. TPH2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TPH2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Cow Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

TPH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Tryptophan Hydroxylase 2 Antibodies

  1. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN372731 : Johansen, Jennings, Cotton, Kuhn: Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A. in Journal of neurochemistry 1996 (PubMed)
    Show all 5 references for ABIN372731

  2. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for ELISA, WB - ABIN1450782 : Walther, Peter, Bashammakh, Hörtnagl, Voits, Fink, Bader: Synthesis of serotonin by a second tryptophan hydroxylase isoform. in Science (New York, N.Y.) 2003 (PubMed)
    Show all 2 references for ABIN1450782

  3. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for FACS, IHC (p) - ABIN955350 : Koning, Newman, Kim, Kunstman, Wolinsky, Malim: Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets. in Journal of virology 2009 (PubMed)
    Show all 2 references for ABIN955350

  4. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for FACS, IHC (p) - ABIN653124 : Khatua, Taylor, Hildreth, Popik: Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. in Virology 2010 (PubMed)
    Show all 2 references for ABIN653124

  5. Mouse (Murine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for ELISA - ABIN768606 : Rahim, Meedeniya, Crane: Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome. in Neuroscience 2014 (PubMed)

  6. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for IHC, ELISA - ABIN185533 : Zhou, Roy, Lipsky, Kuchipudi, Zhu, Taubman, Enoch, Virkkunen, Goldman: Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. in Archives of general psychiatry 2005 (PubMed)

  7. Dog (Canine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for EIA, IHC (p) - ABIN615872 : Cichon, Winge, Mattheisen, Georgi, Karpushova, Freudenberg, Freudenberg-Hua, Babadjanova, Van Den Bogaert, Abramova, Kapiletti, Knappskog, McKinney, Maier, Jamra, Schulze, Schumacher, Propping, Rietschel, Haavik, Nöthen: Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. in Human molecular genetics 2007 (PubMed)

  8. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN2778284 : Tzvetkov, Brockmöller, Roots, Kirchheiner: Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. in Pharmacogenetics and genomics 2008 (PubMed)

More Antibodies against Tryptophan Hydroxylase 2 Interaction Partners

Zebrafish Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. tphR is expressed in serotonergic raphe neurons, similar to tph (show TPH1 Antibodies) genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin

Chimpanzee Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.

Human Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. Carriers of the TPH-2 (show TDO2 Antibodies) allele may be at increased risk for PTSD. COMT (show COMT Antibodies) rs4633C and TPH-2 (show TDO2 Antibodies) rs11178997T alleles jointly explained 7% of the variance in PTSD severity scores. These findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D.

  2. Study demonstrated that 5-HTTLPR (show SLC6A4 Antibodies), VNTR In2, and TPH2 (show TDO2 Antibodies) rs1386497 polymorphisms mediate working memory performance and that their effects on working memory depend on cocaine use of participants

  3. We also found that early family structure directly influences the levels of dysregulation problems in early adolescence, both alone and in interaction with TPH2 (show TDO2 Antibodies).

  4. Chinese Han individuals with at least oners11178997T allele or rs120074175A allele are susceptible to MD even in the relative absence of high-negative life events.

  5. loss of function mutation in Tph2 (show TDO2 Antibodies) results in greater motivation for ethanol consumption under aversive conditions and may confer enhanced sensitivity to alcohol use disorder

  6. TPH2 (show TDO2 Antibodies) expression is regulated by DNA methylation (show HELLS Antibodies) of the TPH2 (show TDO2 Antibodies) promoter region in patients with major depressive disorder.

  7. results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 (show TDO2 Antibodies) gene and suicidal behavior in a Mexican population.

  8. mood disorders and HTR1A (show HTR1A Antibodies) G allele variation, the C-1019G polymorphism of the transcriptional control region of the 5-HT1A receptor (show HTR1A Antibodies), independently predicted the incidence of IFN-induced depression in HCV patients

  9. A potential role of TPH2 (show TDO2 Antibodies) in alcohol dependencies suggested. TPH2 (show TDO2 Antibodies) genetic variability may be also associated with anxiety and aggression traits in alcohol dependent subjects.

  10. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP Antibodies) genes: implication for behavioral influences of vitamin D.

Mouse (Murine) Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT (show DDC Antibodies) neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice

  2. the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.

  3. The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT (show DDC Antibodies)-dependent mechanisms in psychostimulants action.

  4. both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion

  5. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP Antibodies) genes: implication for behavioral influences of vitamin D.

  6. Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.

  7. Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin

  8. This study showed that optogenetic activation of tryptophan hydroxylase 2-expressing serotonergic neurons in rostral ventromedial medulla in vivo induces a long-lasting pain sensitization measured as mechanical allodynia and thermal hyperalgesia. I

  9. While total cell density in the anterior basolateral amygdala did not differ between genotypes, the number and density of the GABAergic interneurons were significantly decreased in Tph2(-/-) mice.

  10. Females exhibit increased sensitivity to at least some of the effects of congenital 5-HT (show DDC Antibodies) deficiency.

Rhesus Monkey Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys

  2. The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT (show DDC Antibodies) metabolism, HPA (show HPSE Antibodies) axis function, and aggressive behaviors

  3. Study identified 17 single nucleotide polymorphisms; 3'-UTR (show UTS2R Antibodies) polymorphisms were significantly associated with HPA (show HPSE Antibodies) axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.

  4. functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2

Tryptophan Hydroxylase 2 (TPH2) Antigen Profile

Protein Summary

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene names and symbols associated with TPH2

  • tryptophan hydroxylase 1b (tph1b) antibody
  • tryptophan hydroxylase 2 (TPH2) antibody
  • tryptophan hydroxylase 2 (tph2) antibody
  • tryptophan 5-hydroxylase 2-like (LOC100627725) antibody
  • tryptophan hydroxylase 2 (Tph2) antibody
  • tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) (tph2) antibody
  • ADHD7 antibody
  • AU043594 antibody
  • Ntph antibody
  • tph1l antibody
  • tph2 antibody
  • tphD2 antibody
  • tphR antibody
  • wu:fq15a04 antibody

Protein level used designations for TPH2

tph1-2 , tryptophan hydroxylase 1, like , tryptophan hydroxylase 2 , tryptophan hydroxylase D2 , neuronal tryptophan hydroxylase , tryptophan 5-hydroxylase 2-like , tryptophan 5-hydroxylase 2 , tryptophan 5-monooxygenase 2 , tryptophan hydroxylase-2 , tph2a , tryptophan hydroxylase R

GENE ID SPECIES
415103 Danio rerio
467070 Pan troglodytes
100303678 Meleagris gallopavo
100459809 Pongo abelii
100486097 Xenopus (Silurana) tropicalis
100588345 Nomascus leucogenys
100627725 Sus scrofa
408026 Gallus gallus
121278 Homo sapiens
481165 Canis lupus familiaris
618062 Bos taurus
216343 Mus musculus
317675 Rattus norvegicus
100009100 Oryctolagus cuniculus
100336620 Bos taurus
100009684 Equus caballus
664730 Macaca mulatta
407712 Danio rerio
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