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WRB encodes a basic nuclear protein of unknown function. Additionally we are shipping WRB Proteins (3) and many more products for this protein.
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WRB gene contains a maternally imprinted differentially methylated region (DMR (show WDR20 Antibodies)). The maternally inherited 5mCpG imprints at the WRB DMR (show WDR20 Antibodies) are uncoupled from the parental allele expression of WRB and ten neighboring genes in twelve biosamples (brain, blood, fallopian tube, fetal large and small intestine, hESCs, large airway epithelial cells, thyroid, muscle, epidermal keratinocytes, ovary, skin, and testis).
Results indicate calcium-modulating cyclophilin ligand (CAML (show CAMLG Antibodies)) and WRB as components of the TRC40 (show ASNA1 Antibodies) receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
The coiled-coil domain of WRB is the binding site for TRC40/Asna1 (show ASNA1 Antibodies).
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, pinball wizard
, tail-anchored protein insertion receptor WRB
, tryptophan-rich basic protein
, tryptophan rich basic protein
, Tryptophan-rich protein
, congenital heart disease 5
, congenital heart disease 5 protein