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WRB encodes a basic nuclear protein of unknown function. Additionally we are shipping WRB Antibodies (21) and many more products for this protein.
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Wrb may have tissue-specific functions in the visual system and heart, or can maintain dual functions even in the same tissue. The selectivity of the defects at sensory neuron ribbon synapses suggests unique biosynthetic demands for cells bearing ribbon synapses, but may also point to a novel role for Wrb acting through the GET pathway in synaptic function.
WRB plays a critical role in synaptic functions in inner-ear hair cells and retinal photoreceptors.
WRB gene contains a maternally imprinted differentially methylated region (DMR (show WDR20 Proteins)). The maternally inherited 5mCpG imprints at the WRB DMR (show WDR20 Proteins) are uncoupled from the parental allele expression of WRB and ten neighboring genes in twelve biosamples (brain, blood, fallopian tube, fetal large and small intestine, hESCs, large airway epithelial cells, thyroid, muscle, epidermal keratinocytes, ovary, skin, and testis).
Results indicate calcium-modulating cyclophilin ligand (CAML (show CAMLG Proteins)) and WRB as components of the TRC40 (show ASNA1 Proteins) receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
The coiled-coil domain of WRB is the binding site for TRC40/Asna1 (show ASNA1 Proteins).
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, pinball wizard
, tail-anchored protein insertion receptor WRB
, tryptophan-rich basic protein
, tryptophan rich basic protein
, Tryptophan-rich protein
, congenital heart disease 5
, congenital heart disease 5 protein