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TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping Tumor Protein p73 Kits (7) and Tumor Protein p73 Proteins (5) and many more products for this protein.
Showing 10 out of 271 products:
Human Polyclonal Tumor Protein p73 Primary Antibody for IP, WB - ABIN265052
Kovalev, Marchenko, Swendeman, LaQuaglia, Moll: Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999
Show all 9 references for ABIN265052
Human Monoclonal Tumor Protein p73 Primary Antibody for IP, WB - ABIN967630
Jost, Marin, Kaelin: p73 is a simian [correction of human] p53-related protein that can induce apoptosis. in Nature 1997
Show all 5 references for ABIN967630
Human Polyclonal Tumor Protein p73 Primary Antibody for IHC, ELISA - ABIN1533498
Kaghad, Bonnet, Yang, Creancier, Biscan, Valent, Minty, Chalon, Lelias, Dumont, Ferrara, McKeon, Caput: Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. in Cell 1997
Show all 2 references for ABIN1533498
Human Polyclonal Tumor Protein p73 Primary Antibody for FACS, IF - ABIN652829
Mai, Huang, Reed, Qian, Smith, Alderete, Jenkins, Smith, Liu: Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. in Genomics 1998
Show all 2 references for ABIN652829
Human Polyclonal Tumor Protein p73 Primary Antibody for WB - ABIN2777952
Wei, OBrien, Vilgelm, Piazuelo, Correa, Washington, El-Rifai, Peek, Zaika: Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. in Gastroenterology 2008
Human Polyclonal Tumor Protein p73 Primary Antibody for WB - ABIN197232
Yuan, Shioya, Ishiko, Sun, Gu, Huang, Lu, Kharbanda, Weichselbaum, Kufe: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. in Nature 1999
Human Polyclonal Tumor Protein p73 Primary Antibody for IP, WB - ABIN318939
Cesková, Valík, Vojt?sek: What we currently know about the structure and function of the p53 homologue - p73 protein: facts, hypotheses and expectations. in Folia biologica 2003
Data show that the Mdm4 (show MDM4 Antibodies)-p73 (show ARHGAP24 Antibodies) axis cannot override the dominant role of p53 (show TP53 Antibodies) in development and tumorigenesis and that Mdm4 (show MDM4 Antibodies) and p73 (show ARHGAP24 Antibodies) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Antibodies) family members.
In vivo inhibition of both p63 (show CKAP4 Antibodies) and p73 (show ARHGAP24 Antibodies) in combination accelerates tumor regression and increases survival of p53 (show TP53 Antibodies)-deficient mice.
Results indicate that p73 (show ARHGAP24 Antibodies) regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.
MDM2 (show MDM2 Antibodies) mediates p73 (show ARHGAP24 Antibodies) ubiquitination
p73 (show ARHGAP24 Antibodies) is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF (show VEGFA Antibodies) and TGFbeta (show TGFB1 Antibodies) signaling
Although mouse TIGAR (show C12orf5 Antibodies) expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Antibodies) or TAp73.
Ribosomal proteins L11 (show RPL11 Antibodies) and L5 activate TAp73 by overcoming MDM2 (show MDM2 Antibodies) inhibition.
the p73 (show ARHGAP24 Antibodies) status has to be considered when studying the regulatory role of p53 (show TP53 Antibodies) protein in gliomagenesis [review]
Suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
p63 (show CKAP4 Antibodies) antagonizes p53 (show TP53 Antibodies) to promote cellular survival, whereas p73 (show ARHGAP24 Antibodies) regulates self-renewal and p53 (show TP53 Antibodies)-mediated apoptosis versus senescence.
our study demonstrates a novel mechanism of PLK2 (show PLK2 Antibodies) in promoting tumor progression, whereby it directly binds to enriched TAp73, catalyzes Ser48 phosphorylation of TAp73, and inhibits TAp73 transcriptional activity
Meta-analysis results suggest that the p73 G4C14-A4T14 polymorphism is associated with an increased risk of cervical squamous cell carcinoma.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
Data indicate tumor suppressors TP73, RASSF1A (show RASSF1 Antibodies), MLH1 (show MLH1 Antibodies) and BRCA1 as possible biomarkers to distinguish Pleomorphic invasive lobular cancer (pleomorphic ILC (show CCL27 Antibodies)} from classic ILC (show CCL27 Antibodies) and infiltrative ductal cancer (IDC (show LMNA Antibodies)).
This review establishes the possibility that p73 is indeed capable of both promoting and inhibiting angiogenesis, depending on the cellular context. [review]
Mechanistic investigations indicated that DNp73 acted by attenuating expression of miR (show MLXIP Antibodies)-885-5p, a direct regulator of the IGF1 (show IGF1 Antibodies) receptor (IGF1R (show IGF1R Antibodies)) responsible for stemness marker expression.
Tyrosine-99 phosphorylation determines the regulation of tumor suppressor p73.
MDM2 (show MDM2 Antibodies) mediates p73 ubiquitination
Mdm2 (show MDM2 Antibodies) overexpression and p73 loss cooperate in genomic instability and tumor development, indicating that the oncogenic function of Mdm2 (show MDM2 Antibodies) is a combined effect of inhibiting p53 (show TP53 Antibodies) and p73 functions
Authors demonstrate that IGFBP3 (show IGFBP3 Antibodies) is a direct TAp73alpha (the p73 isoform that contains the trans-activation domain) target gene and activates the expression of IGFBP3 (show IGFBP3 Antibodies) in actively proliferating cells.
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
tumor protein p73
, tumor protein p73-like
, p53-like transcription factor
, p53-related protein
, transformation related protein 73