Tumor Protein p73 antibody (AA 1-198)

Catalog No. ABIN3029401

This Rabbit Polyclonal antibody specifically detects Tumor Protein p73 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Tumor Protein p73 antibody (AA 1-198) (ABIN3029401)

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tumor Protein p73 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Tumor Protein p73 Antibody

Binding Specificity: AA 1-198

Purpose: p73 Antibody

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (1-198) was used as the immunogen for this p73 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the p73 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the p73 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Tumor Protein p73

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Alternative Name: p73

Background: Tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of the protein. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate it is markedly increased by gamma-irradiation.

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus