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The protein encoded by TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. Additionally we are shipping TSG101 Antibodies (126) and TSG101 Proteins (12) and many more products for this protein.
Showing 2 out of 6 products:
loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept
analysis of genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor
Results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag.
our studies reveal that Tsg101 plays a role in the trafficking of macropinocytosed Kaposi's sarcoma-associated herpesvirus in the endothelial cells
Knockdown of LAMP2A, a CMA-related protein, and TSG101, an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH (show GAPDH ELISA Kits)-HT in AD293 cells and primary cultured rat cortical neurons.
the variant alleles of TSG101 rs2292179 and ATF2 (show ATF2 ELISA Kits) rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively
TSGDelta154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.
Results show that TSG101 bidirectionally modulates cell invasion through regulating MMP-9 (show MMP9 ELISA Kits) mRNA expression in different cell types.
TSG101 plays an important role in the development of hepatocellular carcinoma
Expression of tsg101 mRNA and of TSG101 protein were significantly higher in the oxaliplatin resistant cell line than parent HT-29 cels.
PSAP (show PSAP ELISA Kits) motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.
Stress-internalized EGFR (show EGFR ELISA Kits) is retained intracellularly by continued p38 (show CRK ELISA Kits) activity in a mechanism involving ubiquitin-independent, ESCRT/ALIX (show PDCD6IP ELISA Kits)-dependent incorporation onto intraluminal vesicles (ILVs (show IARS ELISA Kits)) of MVBs
Tsg101 was deleted from mature oligodendroglia in vivo. This resulted in severe spongiform encephalopathy, histopathologically similar to that observed in Mgrn1 (show MGRN1 ELISA Kits) null mutant mice but with a more rapid onset.
BLOS1 (show BLOC1S1 ELISA Kits) interacts with sorting nexin 2 (show SNX2 ELISA Kits) and the ESCRT-I (show VPS28 ELISA Kits) component TSG101 to mediate the sorting of EGFR (show EGFR ELISA Kits) into endosomal compartments
pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.
Tsg101 has a role in expression of EGFR (show EGFR ELISA Kits) and ErbB2 (show ERBB2 ELISA Kits) and preventing induction of autophagy prior to cell death
show that ubiquitin recognition by TSG101 is required for cSMAC formation, T cell receptor (TCR) microcluster signal termination, TCR downregulation.
Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1 (show CDKN1A ELISA Kits)).
Targeted deletion results in cell cycle arrest and p53 (show TP53 ELISA Kits)-independent cell death
our results suggest that Tsg101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer.
the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes
the Tsg101 protein has only weak oncogenic properties
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
, tumor susceptibility Gene-101
, Tumor Susceptibility Gene homolog family member (tsg-101)
, ESCRT-I complex subunit TSG101
, tumor susceptibility gene 101 protein
, tumor susceptibility protein 101
, tumor susceptibility gene 101
, tumor susceptibility gene 10
, tumor susceptibility protein
, Tumor supressor