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Two Pore Segment Channel 2 Proteins (TPCN2)

TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Additionally we are shipping TPCN2 Antibodies (38) and TPCN2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPCN2 309139  
TPCN2 219931 Q8NHX9
TPCN2 233979 Q8BWC0
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Top TPCN2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

TPCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)
Human ,
,
Mouse (Murine) ,
,

More Proteins for Two Pore Segment Channel 2 (TPCN2) Interaction Partners

Zebrafish Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. TPC2-mediated Ca(2 (show CA2 Proteins)+) release from lysosomes may act upstream from RyR- and IP 3R-mediated Ca(2 (show CA2 Proteins)+) release, suggesting that the former might initiate the SR-mediated Ca(2 (show CA2 Proteins)+)-induced-Ca(2 (show CA2 Proteins)+)-release essential for SMC (show DYM Proteins) myogenesis and function.

Human Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.

  2. Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 (show NPC1 Proteins) and TPC2.

  3. Studies suggest that both two-pore channels TPC1 (show TPCN1 Proteins) and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.

  4. TPC2 is thus a potential drug target within a pathogenic LRRK2 (show LRRK2 Proteins) cascade that disrupts Ca(2 (show CA2 Proteins)+)-dependent trafficking in Parkinson disease

  5. SNPs within Tpcn2 are associated with fasting insulin in humans.

  6. NAADP induced marked Ca(2 (show CA2 Proteins)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits

  7. TPC2, but not TPC1 (show TPCN1 Proteins), caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.

  8. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

  9. TPC1 (show TPCN1 Proteins) and TPC2 proteins play a key role in Ebola virus infection and may be effective targets for antiviral therapy.

  10. Notably, NAADP-mediated Ca(2 (show CA2 Proteins)+) release in intact cells is regulated by Mg(2 (show MUC7 Proteins)+), PI(3,5)P2, and P38 (show CRK Proteins)/JNK (show MAPK8 Proteins) kinases, thus paralleling regulation of TPC2 currents.

Mouse (Murine) Two Pore Segment Channel 2 (TPCN2) interaction partners

  1. observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart

  2. TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.

  3. Genetic ablation of endolysosomal TPC1 (show TPCN1 Proteins) or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (show CA2 Proteins)+ signals, and insulin (show INS Proteins) secretion in pancreatic beta cells.

  4. Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin (show INS Proteins) response to a glucose challenge.

  5. Mice lacking TPC2 display muscle atrophy and altered autophagy.

  6. It was concluded that Tpcn1 (show TPCN1 Proteins)/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.

  7. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

  8. Findings indicate that TPC2 have important but distinct roles from TPC1 (show TPCN1 Proteins) in the endo-lysosomal pathway.

  9. TPC2 signaling inhibits embryonic stem cell entry to early neural progenitors, but is required for late neuronal differentiation.

  10. TPC2/NAADP/Ca(2 (show CA2 Proteins)+) signaling alkalinizes lysosomal pH to specifically inhibit the later stage of basal autophagy progression.

TPCN2 Protein Profile

Protein Summary

This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.

Gene names and symbols associated with TPCN2

  • two pore segment channel 2 (tpcn2)
  • two pore segment channel 2 (Tpcn2)
  • two pore segment channel 2 (TPCN2)
  • BC025890 protein
  • D830047E22Rik protein
  • fi42c05 protein
  • im:7140344 protein
  • MGC115225 protein
  • SHEP10 protein
  • TPC2 protein
  • wu:fi42c05 protein
  • zgc:152898 protein

Protein level used designations for TPCN2

two pore calcium channel protein 2 , voltage-dependent calcium channel protein TPC2 , two pore segment channel 2 , two pore calcium channel protein 2-like , two-pore calcium channel protein 2

GENE ID SPECIES
777614 Danio rerio
309139 Rattus norvegicus
423141 Gallus gallus
483683 Canis lupus familiaris
734733 Xenopus laevis
747605 Pan troglodytes
100444397 Pongo abelii
100492057 Xenopus (Silurana) tropicalis
100523421 Sus scrofa
100565414 Anolis carolinensis
219931 Homo sapiens
233979 Mus musculus
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