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TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Additionally we are shipping TPCN2 Antibodies (36) and TPCN2 Kits (2) and many more products for this protein.
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Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.
Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 (show NPC1 Proteins) and TPC2.
Studies suggest that both two-pore channels TPC1 (show TPCN1 Proteins) and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.
TPC2 is thus a potential drug target within a pathogenic LRRK2 (show LRRK2 Proteins) cascade that disrupts Ca(2 (show CA2 Proteins)+)-dependent trafficking in Parkinson disease
SNPs within Tpcn2 are associated with fasting insulin in humans.
NAADP induced marked Ca(2 (show CA2 Proteins)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits
TPC2, but not TPC1 (show TPCN1 Proteins), caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.
These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis
TPC1 (show TPCN1 Proteins) and TPC2 proteins play a key role in Ebola virus infection and may be effective targets for antiviral therapy.
Notably, NAADP-mediated Ca(2 (show CA2 Proteins)+) release in intact cells is regulated by Mg(2 (show MUC7 Proteins)+), PI(3,5)P2, and P38 (show CRK Proteins)/JNK (show MAPK8 Proteins) kinases, thus paralleling regulation of TPC2 currents.
observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart
TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.
Genetic ablation of endolysosomal TPC1 (show TPCN1 Proteins) or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (show CA2 Proteins)+ signals, and insulin (show INS Proteins) secretion in pancreatic beta cells.
Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin (show INS Proteins) response to a glucose challenge.
Mice lacking TPC2 display muscle atrophy and altered autophagy.
It was concluded that Tpcn1 (show TPCN1 Proteins)/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.
Findings indicate that TPC2 have important but distinct roles from TPC1 (show TPCN1 Proteins) in the endo-lysosomal pathway.
TPC2 signaling inhibits embryonic stem cell entry to early neural progenitors, but is required for late neuronal differentiation.
TPC2/NAADP/Ca(2 (show CA2 Proteins)+) signaling alkalinizes lysosomal pH to specifically inhibit the later stage of basal autophagy progression.
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
two pore calcium channel protein 2
, voltage-dependent calcium channel protein TPC2
, two pore segment channel 2
, two pore calcium channel protein 2-like
, two-pore calcium channel protein 2