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Tyrosine Kinase, Non-Receptor, 1 Proteins (TNK1)

The protein encoded by TNK1 belongs to the tyrosine protein kinase family. Additionally we are shipping TNK1 Antibodies (118) and TNK1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNK1 83813 Q99ML2
TNK1 8711 Q13470
Rat TNK1 TNK1 303247  
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Top TNK1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$570.24
Details

TNK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Tyrosine Kinase, Non-Receptor, 1 (TNK1) Interaction Partners

Mouse (Murine) Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. The activated TNK1 potentiates JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) signaling through dual phosphorylation of STAT1 (show STAT1 Proteins) at tyrosine 701 and serine 727 amino acid positions.

  2. data support a negative regulatory role for Kos1 in regulating the Ras-Raf1 (show RAF1 Proteins)-MAPK (show MAPK1 Proteins) growth pathway by a mechanism that requires its autotyrosine kinase activity

  3. Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity

  4. cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1 (show SP1 Proteins), Sp3, AP2 (show TFAP2A Proteins) and MED1 (show MBD4 Proteins) for the m-Tnk1 promoter

Human Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. The activated TNK1 potentiates JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) signaling through dual phosphorylation of STAT1 (show STAT1 Proteins) at tyrosine 701 and serine 727 amino acid positions.

  2. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.

  3. Activated Tnk1 kinase is associated with Hodgkin's lymphoma.

  4. TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha (show TNF Proteins) signaling and therefore cell death.

TNK1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TNK1

  • tyrosine kinase, non-receptor, 1 (TNK1)
  • tyrosine kinase, non-receptor, 1 (Tnk1)
  • Ack-like protein
  • Kos1 protein
  • Tnk1a protein
  • Tnk1b protein

Protein level used designations for TNK1

kinase of embryonic stem cells , non-receptor tyrosine kinase , non-receptor tyrosine-protein kinase TNK1 , CD38 negative kinase 1

GENE ID SPECIES
100061776 Equus caballus
83813 Mus musculus
8711 Homo sapiens
303247 Rattus norvegicus
510356 Bos taurus
489470 Canis lupus familiaris
100735628 Cavia porcellus
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