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U6 SnRNA Biogenesis 1 Proteins (USB1)

USB1 encodes a protein with several conserved domains, however, its exact function is not known. Additionally we are shipping U6 SnRNA Biogenesis 1 Antibodies (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USB1 79650 Q9BQ65
USB1 307643 Q5I0I5
Mouse USB1 USB1 101985 Q91W78
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Top U6 SnRNA Biogenesis 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,641.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,687.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,693.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Rat (Rattus)

More Proteins for U6 SnRNA Biogenesis 1 (USB1) Interaction Partners

Human U6 SnRNA Biogenesis 1 (USB1) interaction partners

  1. USB1 genes from myelodysplastic and myelodysplastic/myeloproliferative neoplasms and AML had 3 unreported variants, 2 in USB1 5'UTR (c.-83G>T and c.-66A>G), 1 in IVS3 (c.450-68dupT) and 1 (<1%) in IVS4 (c.587+21A>G/rs200924980) were detected.

  2. the link between Mpn1 and snRNA stability

  3. Mpn1 associates with the NineTeen Complex, a multiprotein complex that is essential for the maintenance of spliceosome integrity and efficient splicing. [Review]

  4. Data indicate that USB1 measures the appropriate length of the U6 oligo(U) tail by reading the position of a key adenine nucleotide (A102) and pausing 5 uridine residues downstream.

  5. Recombinant hMpn1 is a 3'-to-5' RNA exonuclease (show EXO1 Proteins) that removes uridines from U6 3' ends, generating terminal 2',3' cyclic phosphates in vitro.

  6. characterization of 6 Poikiloderma with Neutropenia patients and mutational repertoire of the gene; detected 2 novel C16orf57 mutations, c.232C>T and c.265 2T>G and the reported c.179delC, c.531delA and c.693 1G>T mutations; bioinformatic prediction of the C16orf57 protein structure denotes a very basic enzymatic function consistent with a housekeeping function

  7. We report three cases of poikiloderma with neutropenia whose clinical presentations, laboratory investigations, and C16orf57 mutation support the diagnosis.

  8. Advanced bioinformatics predicted that C16orf57 encodes a phosphodiesterase whose putative catalytic activity is essential for its function in vivo

  9. Mutations of the C16orf57 gene permit the unification of a distinct group of genetic polikilodermal dermatoses that can be diagnosed as congenital dyskeratosis, Rothmund-Thomson syndrome, poikiloderma-neutropenia.

  10. Identification of a novel C16orf57 mutation in Athabaskan patients with Poikiloderma with Neutropenia.

U6 SnRNA Biogenesis 1 (USB1) Protein Profile

Protein Summary

This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with U6 SnRNA Biogenesis 1 Proteins (USB1)

  • chromosome 16 open reading frame 57 (C6H16orf57)
  • U6 snRNA biogenesis 1 (USB1)
  • U6 snRNA biogenesis 1 (Usb1)
  • U6 snRNA biogenesis 1 (usb1)
  • AA960436 protein
  • c16orf57 protein
  • C18H16orf57 protein
  • hUsb1 protein
  • HVSL1 protein
  • Mpn1 protein
  • PN protein
  • RGD1305215 protein

Protein level used designations for U6 SnRNA Biogenesis 1 Proteins (USB1)

HVSL motif containing 1 , U six biogenesis 1 , U6 snRNA phosphodiesterase , UPF0406 protein C16orf57 , mutated in poikiloderma with neutropenia protein 1 , putative U6 snRNA phosphodiesterase , UPF0406 protein C16orf57 homolog

GENE ID SPECIES
100513409 Sus scrofa
79650 Homo sapiens
510934 Bos taurus
307643 Rattus norvegicus
101985 Mus musculus
379166 Xenopus laevis
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