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UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Proteins (UGT1A1)

UGT1A1 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. Additionally we are shipping UGT1A1 Antibodies (38) and UGT1A1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UGT1A1 54658 P22309
Mouse UGT1A1 UGT1A1 394436 Q63886
Rat UGT1A1 UGT1A1 24861 Q64550
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Top UGT1A1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UGT1A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) Interaction Partners

Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. The UGT1A1*28 and UGT1A1*6 alleles were found to be similar in the Asian populations.

  2. niclosamide was subjected to efficient metabolic reactions hydroxylation and glucuronidation, wherein CYP1A2 (show CYP1A2 Proteins) and UGT1A1 were the main contributing enzymes, respectively.

  3. A thalassemia patient has been found to be a carrier of UGT1A1 and ABCC2 (show ABCC2 Proteins) polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 (show ABCC2 Proteins) and causing a serious adverse reaction.

  4. This trial does not support the use of the intensive treatment with HD-FOLFIRI plus bevacizumab combination for Metastatic Colorectal Cancer in patients with the UGTA1*1/UGT1A1*1 or UGT1A1*1/UGT1A1*28 genotype

  5. For the two-marker haplotype rs11563250G and UGT1A1*1 (rs8175347 TA6), the OR was of 0.17 (P=0.0004).

  6. UGT1A1 G71R mutation is a risk factor for neonatal hyperbilirubinemia in Guangxi Heiyi Zhuang and Han populations. UGT1A1 (TA)7 insertion mutation is not associated with neonatal hyperbilirubinemia in the two ethnic groups.

  7. UGT1A1 polymorphisms (Gly71Arg and TATA promoter) significantly increase the risk of neonatal hyperbilirubinemia [meta-analysis]

  8. compound UGT1A1 gene mutation probably accounts for the disease in the patient manifesting persistent mild unconjugated hyperbilirubinemia

  9. Strong linkage disequilibrium was observed across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an enzyme known to metabolise bilirubin.

  10. UGT1A1-overexpressing HeLa cells were an appropriate tool to accurately depict the inhibition profiles of chemicals against UGT1A1.

Mouse (Murine) UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development

  2. Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT (show DHDDS Proteins)-11 colorectal cancer treatment.

  3. Data observed that OSM (show OSM Proteins) positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM (show OSM Proteins) receptor, via the MAPK (show MAPK1 Proteins) cascade.

  4. suppression of AhR (show AHR Proteins) signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.

  5. Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins)-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress

  6. the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

UGT1A1 Protein Profile

Protein Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Gene names and symbols associated with UGT1A1

  • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1)
  • UDP glucuronosyltransferase 1 family polypeptide A1 (LOC100125517)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100226997)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100229734)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1)
  • BILIQTL1 protein
  • Gnt1 protein
  • HUG-BR1 protein
  • Udpgt protein
  • Udpgt-1a protein
  • UDPGT 1-1 protein
  • Ugt1 protein
  • UGT1A protein
  • UGT1A01 protein
  • UgtBr1 protein

Protein level used designations for UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase 1A1 , uridine diphosphate glucuronosyltransferase 1A1 , UDP-glucuronosyltransferase 1-1 , UDP glycosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase UGT1A01 , UDP glucuronosyltransferase 1 family polypeptide A1 , UDP glycosyl transferase 1A1 , UDP-glucuronosyltransferase 1-1-like , UDP-glucuronosyltransferase 1-A , UGT-1A , UGT1*1 , UGT1-01 , UGT1.1 , bilirubin UDP-glucuronosyltransferase 1-1 , bilirubin UDP-glucuronosyltransferase isozyme 1 , bilirubin-specific UDPGT isozyme 1 , UDP-glucuronosyltransferase 1 family, member 1 , UDP-glucuronosyltransferase 1 family, polypeptide A1 , UDPGT , B1 , UDP-glucuronosyltransferase 1 family member 1

GENE ID SPECIES
449596 Pan troglodytes
493955 Felis catus
574210 Macaca mulatta
751790 Bos taurus
100065342 Equus caballus
100125517 Oryzias latipes
100126701 Papio anubis
100226997 Taeniopygia guttata
100229734 Taeniopygia guttata
100405984 Callithrix jacchus
100511479 Sus scrofa
100534644 Ovis aries
54658 Homo sapiens
394436 Mus musculus
24861 Rattus norvegicus
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