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UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Proteins (UGT1A1)

UGT1A1 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. Additionally we are shipping UGT1A1 Antibodies (38) and UGT1A1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UGT1A1 54658 P22309
Mouse UGT1A1 UGT1A1 394436 Q63886
Rat UGT1A1 UGT1A1 24861 Q64550
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Top UGT1A1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UGT1A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) Interaction Partners

Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. There were not statistical significant differences between carriers of KRAS mutated alleles between SD and PD groups. No significant difference was found between response rates and toxicity and DPD (show DPYD Proteins) or UGT1A1 genotypes. Our results suggested that determination of DPD (show DPYD Proteins) or UGT1A1 genotypes could not be useful for predicting severe toxicity of irinotecan in our population.

  2. Belinostat AUC was increased (P = .003), and t1/2 increased (P = .0009) in UGT1A1*28 and UGT1A1*60 carriers.

  3. Both UGT1A1(*)28 and (*)6 polymorphisms may have an increased risk of irinotecan-induced neutropenia.

  4. A difference in belinostat clearance based on UGT1A1 genotype.

  5. UGT1A1 genotyping is associated with response to chemotherapy in colorectal cancer.

  6. There was no significant difference in grade 3/4 neutropenia between UGT1A1 * 6 wild-type and UGT (show SLC35A2 Proteins)- 1A1 (show SLC45A2 Proteins) * 6 variant genotypes.

  7. smoking or alcohol consumption and the rs4148323 G allele of UGT1A1 act synergistically to increase the risk of laryngeal cancer

  8. Genotype of UGT1A1 and phenotype correlation between Crigler-Najjar syndrome type II and Gilbert syndrome.(

  9. This review presents an overview of the clinical effects of UGT1A1 polymorphisms on the pharmacology of UGT1A1 substrates, with a special focus on the novel histone deacetylase (show HDAC1 Proteins) inhibitor belinostat. [review]

  10. Case Report: mutations in UGT1A1 gene that resulted in residual enzymatic activity in related Iranian subjects with Crigler-Najjar syndrome type I (CN-1 (show NT5C1A Proteins)) and type II.

Mouse (Murine) UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development

  2. Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT (show DHDDS Proteins)-11 colorectal cancer treatment.

  3. Data observed that OSM (show OSM Proteins) positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM (show OSM Proteins) receptor, via the MAPK (show MAPK1 Proteins) cascade.

  4. suppression of AhR (show AHR Proteins) signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.

  5. Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins)-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress

  6. the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

UGT1A1 Protein Profile

Protein Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Gene names and symbols associated with UGT1A1

  • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1)
  • UDP glucuronosyltransferase 1 family polypeptide A1 (LOC100125517)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100226997)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100229734)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1)
  • BILIQTL1 protein
  • Gnt1 protein
  • HUG-BR1 protein
  • Udpgt protein
  • Udpgt-1a protein
  • UDPGT 1-1 protein
  • Ugt1 protein
  • UGT1A protein
  • UGT1A01 protein
  • UgtBr1 protein

Protein level used designations for UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase 1A1 , uridine diphosphate glucuronosyltransferase 1A1 , UDP-glucuronosyltransferase 1-1 , UDP glycosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase UGT1A01 , UDP glucuronosyltransferase 1 family polypeptide A1 , UDP glycosyl transferase 1A1 , UDP-glucuronosyltransferase 1-1-like , UDP-glucuronosyltransferase 1-A , UGT-1A , UGT1*1 , UGT1-01 , UGT1.1 , bilirubin UDP-glucuronosyltransferase 1-1 , bilirubin UDP-glucuronosyltransferase isozyme 1 , bilirubin-specific UDPGT isozyme 1 , UDP-glucuronosyltransferase 1 family, member 1 , UDP-glucuronosyltransferase 1 family, polypeptide A1 , UDPGT , B1 , UDP-glucuronosyltransferase 1 family member 1

GENE ID SPECIES
449596 Pan troglodytes
493955 Felis catus
574210 Macaca mulatta
751790 Bos taurus
100065342 Equus caballus
100125517 Oryzias latipes
100126701 Papio anubis
100226997 Taeniopygia guttata
100229734 Taeniopygia guttata
100405984 Callithrix jacchus
100511479 Sus scrofa
100534644 Ovis aries
54658 Homo sapiens
394436 Mus musculus
24861 Rattus norvegicus
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