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UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) Proteins (UPF3A)

UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF3A Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse UPF3A UPF3A 67031  
Rat UPF3A UPF3A 361176  
UPF3A 65110 Q9H1J1
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Top UPF3A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UPF3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) Interaction Partners

Mouse (Murine) UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) interaction partners

  1. Analysis revealed that UPF3A is a broadly acting nonsense-mediated RNA decay inhibitor. This discovery implies that UPF3A and UPF3B (show UPF3B Proteins) do not primarily work in a complementary or redundant manner as previously supposed; instead, they oppose each other, allowing this paralog pair to serve as a molecular rheostat to modulate the level of gene expression during development.

Human UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) interaction partners

  1. The complex between the interacting domains of human UPF2 and UPF3b (show UPF3B Proteins) at a 1.95 A resolution.

  2. hUpf3a is much less active than hUpf3b (show UPF3B Proteins) to induce NMD and to stimulate translation

  3. Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B (show UPF3B Proteins).

UPF3A Protein Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with UPF3A

  • UPF3 regulator of nonsense transcripts homolog A (yeast) (Upf3a)
  • UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A)
  • UPF3 regulator of nonsense transcripts homolog A (yeast) (upf3a)
  • 2600001C03Rik protein
  • 4930546M19Rik protein
  • HUPF3A protein
  • RENT3A protein
  • si:dkey-21o13.6 protein
  • UPF3 protein
  • UPF3A protein

Protein level used designations for UPF3A

UPF3 regulator of nonsense transcripts homolog A , regulator of nonsense transcripts 3A , UPF3 regulator of nonsense transcripts homolog A (yeast) , regulator of nonsense transcripts 3A-like , hUpf3 , nonsense mRNA reducing factor 3A , up-frameshift suppressor 3 homolog A

GENE ID SPECIES
67031 Mus musculus
361176 Rattus norvegicus
418734 Gallus gallus
452689 Pan troglodytes
529442 Bos taurus
607836 Canis lupus familiaris
100434953 Pongo abelii
65110 Homo sapiens
566608 Danio rerio
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