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UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) Proteins (UPF3B)

UPF3B encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF3B Antibodies (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UPF3B 65109 Q9BZI7
Mouse UPF3B UPF3B 68134  
Rat UPF3B UPF3B 313449  
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Top UPF3B Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

UPF3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) Interaction Partners

Human UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) interaction partners

  1. the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of nonsense-mediated mRNA decay pathway function altering neuronal differentiation.

  2. These findings indicate that SATB2 (show SATB2 Proteins) activates UPF3B expression through binding to its promoter.

  3. Data indicate the mutation p.R430X of UPF3B gene as the genetic etiology in the mental retardation pedigree.

  4. results demonstrate that the UPF3B-dependent NMD pathway is a major regulator of the transcriptome and that its targets have important roles in neuronal cells.

  5. The two cases with renal dysplasia and developmental delay showed remarkable clinical variability despite having the same mutation in UPF3B.

  6. Our results demonstrate that in addition to Lujan-Fryns and FG syndromes, UPF3B protein truncation mutations can cause also nonspecific XLMR (show DLG3 Proteins).

  7. 3.4 A resolution crystal structure of a minimal UPF3b-EJC assembly, consisting of the interacting domains of five proteins (UPF3b, MAGO (show MAGOHB Proteins), Y14 (show RBM8A Proteins), eIF4AIII (show EIF4A3 Proteins), and Barentsz (show CASC3 Proteins)) together with RNA and adenylyl-imidodiphosphate

  8. A conserved domain of hUpf3b mediates an interaction with the EJC protein Y14 (show RBM8A Proteins). Y14 (show RBM8A Proteins) is required for nonsense-mediated decay induced by tethered hUpf3b.

  9. The protein region that mediates this interaction and discriminates between hUpf3a (show UPF3A Proteins) and hUpf3b in NMD function is located in the C-terminal domain and fully contained within a small sequence that is highly conserved in Upf3b but not Upf3a (show UPF3A Proteins) proteins

  10. UPF3B induces nonsense mediated decay in the cytoplasm

Mouse (Murine) UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) interaction partners

  1. Analysis revealed that UPF3A (show UPF3A Proteins) is a broadly acting nonsense-mediated RNA decay inhibitor. This discovery implies that UPF3A (show UPF3A Proteins) and UPF3B do not primarily work in a complementary or redundant manner as previously supposed; instead, they oppose each other, allowing this paralog pair to serve as a molecular rheostat to modulate the level of gene expression during development.

  2. Evidence suggests Upf3b-dependent nonsense-mediated mRNA decay is regulated at multiple levels during development including regulation of expression and sub-cellular localization of Upf3b.

UPF3B Protein Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with UPF3B

  • UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B)
  • UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b)
  • 5730594O13Rik protein
  • AI317193 protein
  • AW541158 protein
  • HUPF3B protein
  • MRXS14 protein
  • RENT3B protein
  • RGD1560264 protein
  • UPF3X protein

Protein level used designations for UPF3B

hUpf3p-X , nonsense mRNA reducing factor 3B , regulator of nonsense transcripts 3B , up-frameshift suppressor 3 homolog B , up-frameshift suppressor 3 homolog on chromosome X , hUPF3B

65109 Homo sapiens
481031 Canis lupus familiaris
616181 Bos taurus
68134 Mus musculus
313449 Rattus norvegicus
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