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Ubiquitin Conjugation Factor E4 B Proteins (UBE4B)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE4B Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat UBE4B UBE4B 298652  
UBE4B 10277 O95155
UBE4B 63958 Q9ES00
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Top UBE4B Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

UBE4B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Ubiquitin Conjugation Factor E4 B (UBE4B) Interaction Partners

Human Ubiquitin Conjugation Factor E4 B (UBE4B) interaction partners

  1. UBE4B overexpression promotes the oncogenic properties of HCC (show FAM126A Proteins) and is correlated with an unfavorable prognosis in HCC (show FAM126A Proteins) patients.

  2. UBE4B regulates p53 (show TP53 Proteins) in breast cancer

  3. We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 (show USP8 Proteins) enable the endosomal sorting and lysosomal degradation of the EGFR (show EGFR Proteins).

  4. UBE4B-mediated growth factor receptor (show RYK Proteins) trafficking may contribute to the poor prognosis of patients who have neuroblastoma (show ARHGEF16 Proteins) tumors with 1p36 deletions.

  5. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.

  6. we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 (show UBE2Q1 Proteins) and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability

  7. data indicate that amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of p53 (show TP53 Proteins) in brain tumors

  8. determined structures of E4B U box free and bound to UbcH5c (show UBE2D3 Proteins) and Ubc4 (show UBE2D2 Proteins) E2s; findings show E4B U box is a monomer stabilized by a network of hydrogen bonds; findings suggest allosteric regulation of UbcH5c (show UBE2D3 Proteins) and Ubc4 (show UBE2D2 Proteins) by E4B U box

  9. A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL (show NUMBL Proteins) tumor suppressor gene in the region at this stage.

  10. E4B serves as a ubiquitin ligase for FEZ1 (show LZTS1 Proteins) and thereby regulates its function but not its degradation

Mouse (Murine) Ubiquitin Conjugation Factor E4 B (UBE4B) interaction partners

  1. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.

  2. Characterization of the UFD2a gene.

  3. UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.

UBE4B Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with UBE4B

  • ubiquitination factor E4B (Ube4b)
  • ubiquitin conjugation factor E4 B (LinJ30.1380)
  • ubiquitin conjugation factor E4 B (LbrM30_V2.1130)
  • ubiquitin conjugation factor E4 B (Tsp_12732)
  • ubiquitin conjugation factor E4 B (Tsp_01624)
  • ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (ube4b)
  • ubiquitination factor E4B (UBE4B)
  • ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (Ube4b)
  • 4930551I19Rik protein
  • 4933406G05Rik protein
  • AU014668 protein
  • D4Bwg0973e protein
  • E4 protein
  • HDNB1 protein
  • mKIAA0684 protein
  • UBOX3 protein
  • UFD2 protein
  • UFD2a protein
  • Ufd2p protein

Protein level used designations for UBE4B

ubiquitin conjugation factor E4 B , ubiquitination factor E4B (UFD2 homolog, yeast) , ubiquitination factor E4B, UFD2 homolog , ubiquitin fusion degradation protein 2 , UFD2A-III/UBE4B-III splice isoform , homologous to yeast UFD2 , homozygously deleted in neuroblastoma 1 , homozygously deleted in neuroblastoma-1 , ubiquitin-fusion degradation protein 2 , ubiquitination factor E4B (homologous to yeast UFD2)

GENE ID SPECIES
298652 Rattus norvegicus
5070994 Leishmania infantum JPCM5
5417638 Leishmania braziliensis MHOM/BR/75/M2904
10899986 Trichinella spiralis
10911805 Trichinella spiralis
100380420 Salmo salar
10277 Homo sapiens
63958 Mus musculus
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