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Ubiquitin Protein Ligase E3 Component N-Recognin 2 Proteins (UBR2)

UBR2 encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Additionally we are shipping UBR2 Antibodies (55) and UBR2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBR2 23304 Q8IWV8
Mouse UBR2 UBR2 224826 Q6WKZ8
Rat UBR2 UBR2 363188  
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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UBR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) interaction partners

  1. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

  2. Study provides functional data for the mouse ubiquitin protein ligase E3 component n-recognin 2 protein.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) interaction partners

  1. Results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta (show MAPK11 Proteins)-C/EBPbeta (show CEBPB Proteins) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.

  2. Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.

  3. insufficiency in UBR2-dependent histone ubiquitination triggers a pachytene checkpoint system, providing a new insight into chromatin remodeling and gene expression regulation

  4. UBR2 ubiquitin ligase and the N-end rule pathway are required for male meiosis and spermatogenesis and for an essential aspect of female embryonic development.

  5. mouse fibroblast cells derived from Ubr2 deficient embryos display genome instability.

  6. UBR1 (show UBR1 Proteins)-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

UBR2 Protein Profile

Protein Summary

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with UBR2

  • ubiquitin protein ligase E3 component n-recognin 2 (UBR2)
  • ubiquitin protein ligase E3 component n-recognin 2 (ubr2)
  • ubiquitin protein ligase E3 component n-recognin 2 (Ubr2)
  • 9930021A08Rik protein
  • AI462103 protein
  • AW540746 protein
  • bA49A4.1 protein
  • C6orf133 protein
  • dJ242G1.1 protein
  • dJ392M17.3 protein
  • E130209G04Rik protein
  • mKIAA0349 protein
  • RP3-392M17.3 protein
  • si:ch211-239i4.2 protein

Protein level used designations for UBR2

ubiquitin protein ligase E3 component n-recognin 2 , rp3-392m17.3 , E3 ubiquitin-protein ligase UBR2 , ubiquitin-protein ligase E3-alpha-2 , ubiquitin-protein ligase E3-alpha-II , N-recognin-2 , ubiquitin ligase E3 alpha-II

GENE ID SPECIES
100522688 Sus scrofa
100009912 Monodelphis domestica
100170193 Xenopus (Silurana) tropicalis
100542516 Meleagris gallopavo
559136 Danio rerio
734725 Xenopus laevis
421387 Gallus gallus
23304 Homo sapiens
474903 Canis lupus familiaris
527153 Bos taurus
224826 Mus musculus
363188 Rattus norvegicus
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