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anti-Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) Antibodies

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Additionally we are shipping USP17L2 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse USP17L2 USP17L2 109998  
USP17L2 377630 Q6R6M4
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Top anti-USP17L2 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB USP17L2 Antibody (C-term) western blot analysis in A375 cell line lysates (35 µg/lane). This demonstrates the USP17L2 antibody detected the USP17L2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged DUB3 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP17L2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart WB Suggested Anti-USP17L2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB USP17L2 Antibody (C-term)  western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the USP17L2 antibody detected the USP17L2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged DUB3 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB USP17L2 antibody used at 0.2-1 ug/ml to detect target protein. 50 μg Log in to see 7 to 9 Days
$473.93
Details

USP17L2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Top referenced anti-USP17L2 Antibodies

  1. Human Monoclonal USP17L2 Primary Antibody for ELISA, WB - ABIN393724 : Pereg, Liu, ORourke, Sagolla, Dey, Komuves, French, Dixit: Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. in Nature cell biology 2010 (PubMed)
    Show all 4 references for ABIN393724

  2. Human Polyclonal USP17L2 Primary Antibody for EIA, WB - ABIN955487 : Burrows, McGrattan, Rascle, Humbert, Baek, Johnston: DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN955487

More Antibodies against USP17L2 Interaction Partners

Mouse (Murine) Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. Using a reporter assay, we show that NCoA1 potentiates Esrrb-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 splice variant NCoA1 and Esrrb

  2. We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A (show CDC25A Antibodies) destabilization, while forced Dub3 expression in ESCs (show NR2E3 Antibodies) becomes lethal upon differentiation

Human Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 (show HDAC2 Antibodies) is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

  2. These data indicate that the Dub3 might be a valuable biomarker for the prediction of ovarian cancer prognosis and Dub3 inhibition might be a potential strategy for ovarian cancer treatment.

  3. Dub3 counteracts H2AX E3 ligases RNF8 and RNF168. Moreover, Dub3 and H2AX interact and Dub3 deubiquitinates H2AX in vitro.

  4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1 (show USP36 Antibodies), DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review]

  5. As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation.

  6. human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation.

  7. Identifies DUB3 as being one of 30 genes with the most variable copy numbers in three human genomes.

USP17L2 Antigen Profile

Protein Summary

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis.

Gene names and symbols associated with USP17L2

  • deubiquitinating enzyme 3 (Dub3) antibody
  • ubiquitin specific peptidase 17-like 2 (USP17L2) antibody
  • ubiquitin specific peptidase 17-like E (Usp17le) antibody
  • ubiquitin specific peptidase 17-like family member 2 (USP17L2) antibody
  • DUB-3 antibody
  • DUB3 antibody
  • Dub6 antibody
  • EG625530 antibody
  • Gm6596 antibody
  • USP17 antibody
  • Usp17l2 antibody

Protein level used designations for USP17L2

deubiquitinating enzyme 3 , ubiquitin specific peptidase 17-like 2 , deubiquitinating enzyme 17-like protein 2 , deubiquitinating enzyme 6 , deubiquitinating protein 3 , deubiquitinating protein 6 , ubiquitin carboxyl-terminal hydrolase 17 , ubiquitin carboxyl-terminal hydrolase 17-like protein 2 , ubiquitin thioesterase 17-like protein 2 , ubiquitin thiolesterase 17-like protein 2 , ubiquitin-specific-processing protease 17-like protein 2

GENE ID SPECIES
109998 Mus musculus
695235 Macaca mulatta
625530 Mus musculus
377630 Homo sapiens
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