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The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Additionally we are shipping USP28 Kits (7) and USP28 Proteins (5) and many more products for this protein.
Showing 10 out of 81 products:
Human Polyclonal USP28 Primary Antibody for ICC, IF - ABIN4364574
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Polyclonal USP28 Primary Antibody for IHC (p), IHC - ABIN409110
Popov, Herold, Llamazares, Schülein, Eilers: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. in Cell cycle (Georgetown, Tex.) 2007
Human Polyclonal USP28 Primary Antibody for EIA, WB - ABIN357566
Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. in Nature reviews. Genetics 2003
These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity.
Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR (show MLXIP Antibodies)-4295.
findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands.
Dual regulation of Fbw7 (show FBXW7 Antibodies) activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 (show FBXW7 Antibodies) substrates, which is equivalently disrupted by loss or overexpression of Usp28.
identified Usp28 as a c-MYC (show MYC Antibodies) target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC (show MYC Antibodies) form a positive feedback loop that maintains high c-MYC (show MYC Antibodies) protein levels in tumors
USP28 has a chain preference activity for Lys (show LYZ Antibodies)(11), Lys (show LYZ Antibodies)(48), and Lys (show LYZ Antibodies)(63) diubiquitin (show UBD Antibodies) linkages
Usp28 expression was indentified as a independent predictors of survival (P = 0.001) and potentially valuable in prognostic evaluation of bladder cancer
Study reveals a critical mechanism underlying the epigenetic regulation by USP28.
USP28 is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization.
USP28 gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 (show FBXW7 Antibodies) and Usp28, modulate intestinal homeostasis and cancer.
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).
ubiquitin specific peptidase 28
, ubiquitin carboxyl-terminal hydrolase 28-like
, ubiquitin specific protease 28
, ubiquitin carboxyl-terminal hydrolase 28
, deubiquitinating enzyme 28
, ubiquitin carboxyl-terminal hydrolase 28 variant 1
, ubiquitin thioesterase 28
, ubiquitin thiolesterase 28
, ubiquitin-specific-processing protease 28