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Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Additionally we are shipping and many more products for this protein.
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our studies highlight Jak1 (show JAK1 Antibodies) as the first identified substrate for USP6, and they offer a mechanistic rationale for the clinical investigation of Jak (show JAK3 Antibodies) and STAT3 (show STAT3 Antibodies) inhibitors as therapeutics for the treatment of bone and soft tissue tumors along with other neoplasms driven by USP6 overexpression
Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis
It was shown that TRE17 activates the classical NF-kappa B (show NFKB1 Antibodies) pathway through an atypical mechanism that does not involve IkappaB degradation. Optimal activation of NF-kappa B (show NFKB1 Antibodies) by TRE17 required both catalytic subunits of IkappaB kinase (show CHUK Antibodies).
USP6 fluorescence in-situ hybridization is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration.
the deubiquitylase ubiquitin-specific protease 6 (USP6) as a potent activator of Wnt (show WNT2 Antibodies) signaling. USP6 enhances Wnt (show WNT2 Antibodies) signaling by deubiquitylating Fzds, thereby increasing their cell-surface abundance.
TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis
8 of the 9 giant cell reparative granulomas from hands and feet showed rearrangements of the USP6 gene compared with none of 8 gnathic lesions
we discuss the clinicopathologic features, molecular pathology, and pathogenesis of ABC (show ABCB6 Antibodies) and nodular fasciitis in relation to USP6
identification of a USP6 gene rearrangement is helpful in making a diagnosis of nodular fasciitis.
manipulating USP6 expression levels alters the ability of cells to migrate and to divide. Cell proliferation and progression through cytokinesis depend on USP6 expression
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
TBC1D3 and USP32 fusion
, deubiquitinating enzyme 6
, hyperpolymorphic gene 1
, proto-oncogene TRE-2
, tre-2 oncogene
, ubiquitin carboxyl-terminal hydrolase 6
, ubiquitin specific peptidase 6-
, ubiquitin specific protease 6 (Tre-2 oncogene)
, ubiquitin thioesterase 6
, ubiquitin thiolesterase 6
, ubiquitin-specific protease USP6
, ubiquitin-specific-processing protease 6