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Ubiquitin-Conjugating Enzyme E2B Proteins (UBE2B)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2B Antibodies (46) and UBE2B Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBE2B 7320 P63146
UBE2B 22210 P63147
UBE2B 81816 P63149
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Top UBE2B Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 16 Days
$173.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,337.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,337.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,337.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$385.00
Details
HOST_HEK293 Human His tag   500 μg Log in to see 5 Days
$1,732.50
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 10 to 12 Days
$237.60
Details

UBE2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)
Rat (Rattus)

Top referenced UBE2B Proteins

  1. Human UBE2B Protein expressed in Escherichia coli (E. coli) - ABIN667135 : Koken, Hoogerbrugge, Jasper-Dekker, de Wit, Willemsen, Roest, Grootegoed, Hoeijmakers: Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. in Developmental biology 1996 (PubMed)
    Show all 2 references for ABIN667135

More Proteins for Ubiquitin-Conjugating Enzyme E2B (UBE2B) Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2B (UBE2B) interaction partners

  1. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.

  2. A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population.

  3. RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (show CBX5 Proteins) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway

  4. UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.

  5. RNF168 (show RNF168 Proteins), in complex with RAD6A (show ube2a Proteins) or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

  6. UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men.

  7. beta-catenin (show CTNNB1 Proteins) and Rad6B interacting regions, were identified.

  8. Hydroquinone could upregulate the expression of Rad6B in L-02 hepatic cells.

  9. The Rad6-Rad18 (show RAD18 Proteins) enzyme plays an essential role in promoting replication through DNA lesions by translesion synthesis in mammalian cells.

  10. RAD6 can form a ternary complex with MDM2 (show MDM2 Proteins) and p53 (show TP53 Proteins) that contributes to the degradation of p53 (show TP53 Proteins).

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2B (UBE2B) interaction partners

  1. RNF168 (show RNF168 Proteins), in complex with RAD6A (show ube2a Proteins) or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

  2. These results suggest that Ube2b, as a direct androgen receptor transcriptional target in Sertoli cells, mediates the function of androgen recpetor in spermatogenesis by promoting H2A ubiquitylation.

  3. HR6B represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids.

  4. The present findings reveal a specific requirement for the ubiquitin-conjugating activity of HR6B in relation to dynamic aspects of the synaptonemal complex and meiotic recombination in spermatocytes.

  5. Ube2b deficient mice are shown to present male infertility and sperm head shape anomalies.

  6. HR6B exerts control over different histone modifications in spermatocytes and spermatids, and that this function contributes to the postmeiotic maintenance of X chromosome silencing.

UBE2B Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.

Gene names and symbols associated with UBE2B

  • Ubiquitin-conjugating enzyme E2 B (ube2b)
  • zgc:55512 (zgc:55512)
  • ubiquitin-conjugating enzyme E2B (RAD6 homolog) (ube2b)
  • ubiquitin-conjugating enzyme E2B (ube2b)
  • ubiquitin-conjugating enzyme E2B (UBE2B)
  • ubiquitin-conjugating enzyme E2B (RAD6 homolog) (UBE2B)
  • ubiquitin-conjugating enzyme E2B (Ube2b)
  • 2610301N02Rik protein
  • E2-14k protein
  • E2-17kDa protein
  • fc79h10 protein
  • HHR6B protein
  • HR6B protein
  • mHR6B protein
  • Rad6b protein
  • UBC2 protein
  • wu:fc79h10 protein
  • zgc:100921 protein

Protein level used designations for UBE2B

Ubiquitin-conjugating enzyme E2 B , ubiquitin-conjugating enzyme E2 B , ubiquitin-conjugating enzyme E2B (RAD6 homolog) , ubiquitin-conjugating enzyme E2 , E2 protein , RAD6 homolog B , ubiquitin carrier protein B , ubiquitin-conjugating enzyme E2-17 kDa , ubiquitin-protein ligase B , E214K , ubiquitin-conjugating enzyme E2B, RAD6 homology , E2(14k) , ubiquitin conjugating enzyme , ubiquitin-conjugating enzyme E2(14k) , ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) , ubiquitin-conjugating enzyme E2B, RAD6 homolog , HR6B , ubiquitin conjugating-protein

GENE ID SPECIES
100286422 Salmo salar
100301680 Oncorhynchus mykiss
325470 Danio rerio
437020 Danio rerio
448706 Xenopus (Silurana) tropicalis
462065 Pan troglodytes
474683 Canis lupus familiaris
710678 Macaca mulatta
100381250 Ovis aries
7320 Homo sapiens
22210 Mus musculus
81816 Rattus norvegicus
443745 Xenopus laevis
100513527 Sus scrofa
512207 Bos taurus
100009132 Oryctolagus cuniculus
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