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Ubiquitin-Conjugating Enzyme E2M Proteins (ube2m)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2M Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ube2m 9040 P61081
Mouse ube2m ube2m 22192 P61082
Rat ube2m ube2m 361509  
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Top Ubiquitin-Conjugating Enzyme E2M Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$137.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,414.50
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,432.83
Details
Yeast Candida His tag   1 mg Log in to see 56 to 66 Days
$2,445.67
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$443.33
Details

ube2m Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

Top referenced Ubiquitin-Conjugating Enzyme E2M Proteins

  1. Human ube2m Protein expressed in Escherichia coli (E. coli) - ABIN1098637 : Huang, Miller, Mathew, Cassell, Holton, Roussel, Schulman: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. in Nature structural & molecular biology 2004 (PubMed)
    Show all 2 references for ABIN1098637

More Proteins for Ubiquitin-Conjugating Enzyme E2M (ube2m) Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2M (ube2m) interaction partners

  1. Polymorphisms in the UBE2M gene are associated with cetuximab efficacy in colorectal cancer.

  2. E1 (NAE1 (show NAE1 Proteins) and UBA3 (show UBA3 Proteins)) and E2 (UBC12) enzymes, as well as global NEDD8 (show NEDD8 Proteins) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma

  3. UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

  4. Distinct preferences of UBC12 and UBE2F (show UBE2F Proteins) peptides for inhibiting different DCNLs, including the oncogenic DCNL1 (show DCUN1D1 Proteins).

  5. Our results demonstrate a role for UBE2M in mediating cytotoxicity of gemcitabine in human urothelial carcinoma cells.

  6. crystal structure of a complex between the C-terminal domain from NEDD8 (show NEDD8 Proteins)'s heterodimeric E1 (APPBP1 (show NAE1 Proteins)-UBA3 (show UBA3 Proteins)) and the catalytic core domain of NEDD8 (show NEDD8 Proteins)'s E2 (Ubc12)

  7. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2M (ube2m) interaction partners

  1. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

Ubiquitin-Conjugating Enzyme E2M (ube2m) Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.

Gene names and symbols associated with ube2m

  • ubiquitin-conjugating enzyme E2M (ube2m)
  • ubiquitin-conjugating enzyme E2M (LOC692934)
  • ubiquitin-conjugating enzyme E2M (UBE2M)
  • ubiquitin-conjugating enzyme E2M (LOC100341057)
  • NEDD8-conjugating enzyme (ube2m)
  • ubiquitin-conjugating enzyme E2M (Ube2m)
  • 2510040H03Rik protein
  • DDBDRAFT_0204633 protein
  • DDBDRAFT_0238042 protein
  • DDB_0204633 protein
  • DDB_0238042 protein
  • hUbc12 protein
  • Ubc-rs2 protein
  • UBC12 protein

Protein level used designations for ube2m

NEDD8 carrier protein , NEDD8 protein ligase , NEDD8-conjugating enzyme Ubc12 , ubiquitin-conjugating enzyme E2M (UBC12 homolog) , ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) , ubiquitin-conjugating enzyme E2M , ubiquitin-conjugating enzyme E2 M , ubiquitin carrier protein M , ubiquitin-protein ligase M , yeast UBC12 homolog , UBC12 homolog, yeast , ubiquitin C, related sequence 2

GENE ID SPECIES
394553 Xenopus (Silurana) tropicalis
692934 Bombyx mori
742993 Pan troglodytes
100341057 Oryctolagus cuniculus
8623215 Dictyostelium discoideum AX4
9040 Homo sapiens
22192 Mus musculus
361509 Rattus norvegicus
446800 Xenopus laevis
484221 Canis lupus familiaris
613343 Bos taurus
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