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Unc-5 Homolog C (C. Elegans) Proteins (Unc5c)

Unc5c product belongs to the UNC-5 family of netrin receptors. Additionally we are shipping Unc5c Antibodies (90) and Unc5c Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Unc5c 8633 O95185
Mouse Unc5c Unc5c 22253 O08747
Unc5c 362049 Q761X5
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Top Unc5c Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,920.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Unc5c Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

More Proteins for Unc-5 Homolog C (C. Elegans) (Unc5c) Interaction Partners

Human Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. identify the V-2 domain of netrin-1 (show NTN1 Proteins) to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 (show UNC5B Proteins)

  2. we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers.

  3. T835M (rs137875858) in the UNC5C wa (show CA3 Proteins)s associated with late-onset Alzheimer disease and increased cell death in HEK293 cells.

  4. UNC5C mutations are very rare in familial and sporadic colorectal carcinomas.

  5. TNM (show ODZ1 Proteins) stage 1 hepatocellular carcinoma (HCC (show FAM126A Proteins)) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC (show FAM126A Proteins).

  6. knockdown of DSCAM (show DSCAM Proteins) inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn (show FYN Proteins) as well as the interaction of UNC5C with Fyn (show FYN Proteins). The double knockdown of both receptors abolishes the induction of Fyn (show FYN Proteins) tyrosine phosphorylation by netrin-1 (show NTN1 Proteins)

  7. Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.

  8. UNC5C acts as a tumour suppressor in RCC (show XRCC1 Proteins) and is down-regulated in RCC (show XRCC1 Proteins). Loss of heterozygosity and DNA methylation (show HELLS Proteins) contribute to the inactivation of UNC5C in renal cell carcinoma (show MOK Proteins).

  9. UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.

  10. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 (show NTN1 Proteins) availability by inducing apoptosis

Mouse (Murine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.

  2. UNC5c expression is enriched in CA3 (show CA3 Proteins) hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.

  3. Unc5C and DCC (show DCC Proteins) act downstream of Ctip2 and Satb2 (show SATB2 Proteins) and contribute to corpus callosum formation.

  4. unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc (show DCC Proteins) haploinsufficiency and is observed after adolescence.

  5. this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain.

  6. These results support an important role for UNC5C in spinal accessory motor neuron development.

  7. repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis

  8. The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway.

Cow (Bovine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. Cows with higher conception rates carried the A+169G polymorphism in the 3' untranslated region of UNC5C (show UNC5B Proteins), which transcripts were expressed at higher levels than those carrying the G polymorphism, which might cause poor preimplantation embryo development.

Unc5c Protein Profile

Protein Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin\; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

Gene names and symbols associated with Unc5c

  • unc-5 homolog C (C. elegans) (UNC5C)
  • unc-5 homolog C (C. elegans) (Unc5c)
  • unc-5 homolog C (C. elegans) (unc5c)
  • 6030473H24 protein
  • AI047720 protein
  • B130051O18Rik protein
  • rcm protein
  • UNC5C protein
  • Unc5h3 protein
  • wu:fb03d07 protein

Protein level used designations for Unc5c

unc-5 homolog C (C. elegans) , netrin receptor UNC5C-like , netrin receptor UNC5C , protein unc-5 homolog 3 , protein unc-5 homolog C , unc-5 homolog 3 , unc5 (C.elegans homolog) c , UNC-5 homolog 3 , rostral cerebellar malformation protein , unc5 homolog 3 , fb03d07 , UNC5-like protein 3 , cUNC-5H3

GENE ID SPECIES
471254 Pan troglodytes
100599418 Nomascus leucogenys
705591 Macaca mulatta
100016333 Monodelphis domestica
100065541 Equus caballus
100351024 Oryctolagus cuniculus
100397357 Callithrix jacchus
100443113 Pongo abelii
8633 Homo sapiens
478485 Canis lupus familiaris
22253 Mus musculus
557316 Danio rerio
395101 Gallus gallus
533256 Bos taurus
362049 Rattus norvegicus
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