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Unc5c product belongs to the UNC-5 family of netrin receptors. Additionally we are shipping Unc5c Antibodies (96) and Unc5c Kits (10) and many more products for this protein.
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The objective of this study is to investigate the influence of UNC5C loci on the neuroimaging of strategic regions of Alzheimer's disease.
we identified ENC1 (show ENC1 Proteins) and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evidence supporting a potential role in the dissociation of cognition and neuropathology in an aging population.
the results suggest that UNC5C methylation may be an earlier event in the development of colorectal cancer, which was negatively correlated with protein expression.
7 of these 8 variants do not cause increased colorectal cancer risk, including UNC5C c.1882_1883delinsAA (p.A628K).
Data show that overexpression of wild-type netrin receptor UNC5C (UNC5C) causes low-grade death, which is intensified by an Alzheimer Disease-linked mutation T835M, and mediated by amyloid beta precursor protein (APP (show APP Proteins)).
identify the V-2 domain of netrin-1 (show NTN1 Proteins) to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 (show UNC5B Proteins)
we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers.
T835M (rs137875858) in the UNC5C wa (show CA3 Proteins)s associated with late-onset Alzheimer disease and increased cell death in HEK293 cells.
UNC5C mutations are very rare in familial and sporadic colorectal carcinomas.
TNM (show ODZ1 Proteins) stage 1 hepatocellular carcinoma (HCC (show FAM126A Proteins)) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC (show FAM126A Proteins).
Here, we report that dissociation of UNC5C and polymerized TUBB3 (show TUBB3 Proteins), the highly dynamic beta-tubulin (show TUBB Proteins) isoform in neurons, is essential for netrin-1 (show NTN1 Proteins)/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (show NEU2 Proteins) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 (show TUBB3 Proteins) mutations.
UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.
UNC5c expression is enriched in CA3 (show CA3 Proteins) hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.
Unc5C and DCC (show DCC Proteins) act downstream of Ctip2 and Satb2 (show SATB2 Proteins) and contribute to corpus callosum formation.
unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc (show DCC Proteins) haploinsufficiency and is observed after adolescence.
this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain.
These results support an important role for UNC5C in spinal accessory motor neuron development.
repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis
The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway.
Cows with higher conception rates carried the A+169G polymorphism in the 3' untranslated region of UNC5C (show UNC5B Proteins), which transcripts were expressed at higher levels than those carrying the G polymorphism, which might cause poor preimplantation embryo development.
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin\; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.
unc-5 homolog C (C. elegans)
, netrin receptor UNC5C-like
, netrin receptor UNC5C
, protein unc-5 homolog 3
, protein unc-5 homolog C
, unc-5 homolog 3
, unc5 (C.elegans homolog) c
, UNC-5 homolog 3
, rostral cerebellar malformation protein
, unc5 homolog 3
, UNC5-like protein 3