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Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP1 Kits (21) and UCP1 Proteins (17) and many more products for this protein.
Showing 10 out of 110 products:
Human Monoclonal UCP1 Primary Antibody for ELISA, WB - ABIN393398
Kim, Lee: The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women. in International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2010
Show all 5 references for ABIN393398
Human Monoclonal UCP1 Primary Antibody for WB - ABIN4948274
Hancock, Clark, Qian, Di Rienzo: Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance. in Molecular biology and evolution 2010
Show all 5 references for ABIN4948274
Human Polyclonal UCP1 Primary Antibody for IHC, ELISA - ABIN251297
Liu, Singh, Choi, Lee, Keramati, Samuel, Lifton, Shulman, Mani: Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. in The Journal of biological chemistry 2012
Show all 3 references for ABIN251297
Human Polyclonal UCP1 Primary Antibody for IF (p), IHC (p) - ABIN675413
Lu, Ji, Zhang, Zhang, Zhang, An, Liu, Zheng: Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. in Endocrinology 2012
Show all 2 references for ABIN675413
Human Polyclonal UCP1 Primary Antibody for ELISA, WB - ABIN185512
Ishigaki, Katagiri, Yamada, Ogihara, Imai, Uno, Hasegawa, Gao, Ishihara, Shimosegawa, Sakoda, Asano, Oka: Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. in Diabetes 2005
The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.
Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.
Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.
The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]
Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.
An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.
UCP1 dietary activation can alleviate obesity. (Review)
The molecular features of UCP1 support a conventional mitochondrial carrier (show UCP3 Antibodies)-like mechanism. (Review)
The history of discovery of UCP1, the mitochondrial uncoupling protein (show UCP3 Antibodies) of brown adipocyte, has been described. (Review)
Transcriptional regulation of the UCP1 protein in obesity and normal thermogenesis has been described. (Review)
The H+ transport mediated by UCP1 was shown to be electrophoretic with a linear relation to the membrane potential. (Review)
In the absence of purine nucleotides, UCP1 presents a high ohmic proton conductance that does not require the presence of activating ligands, such as fatty acids or retinoids.
UCP1 is a transporter for H(+) and fatty acid anions. (Review)
In inguinal white adipose tissue (iWAT) of mice fed a high-fat diet (HFD), Ucp1 level decreases concomitantly with increases in Cnot7 (show CNOT7 Antibodies) and its interacting partner Tob (show TDO2 Antibodies).
Findings suggest that polymorphisms in SIRT6 (show SIRT6 Antibodies)/UCP1 genes may be important for increased carotid plaque burden and echodensity
UCP1 -3826 A>G polymorphism is associated with weight, body fat mass, and risk of type 2 diabetes mellitus in obese individuals candidates for bariatric surgery.
Targeted mitochondrial uncoupling in adipose tissue and skeletal muscle of UCP1-transgenic mice increased substrate metabolism and ameliorates obesity. (Review)
In the absence of regulators (fatty acids, retinoids), rodent UCP1 presents a high ohmic proton conductance that cannot be detected in human UCP1.
The uncoupling of oxidative phosphorylation through a proton conductance pathway across the mitochondrial inner membrane is the mechanism for heat production in brown adipose tissue regulated by UCP1. (Review)
Brown adipocytes trough their unique mitochondrial UCP1 protein burn glucose and lipids to perform thermogenesis in order to survive in cold environments. (Review)
Brown and beige (show LYST Antibodies) adipose tissues activate UCP1 protein in dissimilar fashion in response to cold temperature and depending on adipocytes differentiation state.
ATGL (show PNPLA2 Antibodies) activity is required for UCP1 activation in intact adipocytes. (Review)
Metabolically inert perfluorinated fatty acids directly activate brown adipose tissue UCP1.
Mice acclimatized to thermoneutrality revealed that Cpt2A-null interscapular brown adipose tissue failed to induce the expression of thermogenic genes such as Ucp1 and Pgc1a (show PPARGC1A Antibodies).
Data show that fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of mitochondrial uncoupling protein 1 (show SLC25A19 Antibodies) (UCP1) and beta3 adrenergic receptor (show ADRB3 Antibodies) (beta3AR).
Skin temperature in the interscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positive control, but not in Cox7a1 (show COX7A1 Antibodies) knockout pups
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (show UCP2 Antibodies) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
These results suggest that CIDE-A (show CIDEA Antibodies) and UCP1 are regulated by insulin (show INS Antibodies) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
uncoupling protein 1 (mitochondrial, proton carrier)
, uncoupling protein 1
, mitochondrial brown fat uncoupling protein 1
, solute carrier family 25 member 7
, UCP 1
, uncoupling protein 1 UCP1
, uncoupling protein 1, mitochondrial
, uncoupling protein, mitochondrial
, mitochondrial, proton carrier
, Solute carrier family 25 member 7