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Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP1 Kits (21) and UCP1 Proteins (9) and many more products for this protein.
Showing 10 out of 106 products:
Human Monoclonal UCP1 Primary Antibody for WB - ABIN393760
Kim, Lee: The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women. in International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2010
Show all 5 references for ABIN393760
Human Monoclonal UCP1 Primary Antibody for ELISA, WB - ABIN393398
Hancock, Clark, Qian, Di Rienzo: Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance. in Molecular biology and evolution 2010
Show all 5 references for ABIN393398
Human Polyclonal UCP1 Primary Antibody for IF (p), IHC (p) - ABIN675413
Lu, Ji, Zhang, Zhang, Zhang, An, Liu, Zheng: Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. in Endocrinology 2012
Show all 2 references for ABIN675413
Dog (Canine) Polyclonal UCP1 Primary Antibody for WB - ABIN374628
Ishigaki, Katagiri, Yamada, Ogihara, Imai, Uno, Hasegawa, Gao, Ishihara, Shimosegawa, Sakoda, Asano, Oka: Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. in Diabetes 2005
The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.
Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.
Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.
The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]
Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.
An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.
Findings suggest that polymorphisms in SIRT6 (show SIRT6 Antibodies)/UCP1 genes may be important for increased carotid plaque burden and echodensity
UCP1 -3826 A>G polymorphism is associated with weight, body fat mass, and risk of type 2 diabetes mellitus in obese individuals candidates for bariatric surgery.
UCP1 and UCP3 (show UCP3 Antibodies) expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery.
this study reveals that human adipose-derived stromal/progenitor cells can be readily differentiated into beige (show LYST Antibodies) adipocytes that, upon activation, undergo uncoupling protein 1-dependent thermogenesis.
This study suggests that the SNP rs1800592 in the UCP1 gene is associated with increased risk of PDR in the Chinese type 2 diabetes mellitus population.
Genotype and allele distributions of UCP1, UCP2 (show UCP2 Antibodies) and UCP3 (show UCP3 Antibodies) polymorphisms did not differ significantly between obese and non-obese Type 2 Diabetes Mellitus patients.[Meta-analysis]
Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.
Meta-analysis. There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences.
By the application of these findings, we demonstrate that UCP1 is functionally thermogenic in intact brite adipocytes and adrenergic UCP1 activation is largely dependent on adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) rather than hormone sensitive lipase (HSL (show LIPE Antibodies)).
BMI and TBF were significantly different among UCPI -3826A/G and UCP3 (show UCP3 Antibodies) -55C/T genotype combinations, suggesting the existence of a gene interaction between UCP1 and UCP3 (show UCP3 Antibodies) in influencing obesity and adiposity in multiethnic Malaysians.
Skin temperature in the interscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positive control, but not in Cox7a1 (show COX7A1 Antibodies) knockout pups
PKA-dependent IRE1alpha (show ERN1 Antibodies)-XBP1 (show XBP1 Antibodies) activation is crucial for the transcriptional induction of Ucp1 in brown adipocytes.
FGF21 (show FGF21 Antibodies)-mediated improvements in clearance of a glucose challenge require UCP1.
Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 (show HDAC1 Antibodies) from promoters of Ucp1/Pgc1a (show PPARGC1A Antibodies), to up-regulation of histone H3 (show HIST3H3 Antibodies) acetylation, to dissociation of polycomb (show CBX2 Antibodies) repressive complexes, and to up-regulation of thermogenesis.
thermogenic mitochondrial reactive oxygen species alter the redox status of cysteine thiols in brown adipose tissue to drive increased respiration, and that Cys253 of UCP1 is a key target
abundance decreased even more in cold-acclimated UCP1 knockout mice
These data indicate that several important metabolic endpoints of FGF21 (show FGF21 Antibodies) are UCP1 independent
Data suggest that expression of Ucp1 in skeletal muscle can be regulated by dietary factors; the prebiotic epilactose prevents high-fat diet-induced obesity apparently via up-regulation of Ucp1 expression in skeletal muscles and brown adipose tissue.
Data indicate that uncoupling protein 1 (UCP1) is required for the dietary methionine restriction (MR)-induced increase in energy expenditure (EE) but not insulin (show INS Antibodies) sensitivity.
UCP1 and SLN (show SLN Antibodies) are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (show UCP2 Antibodies) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
These results suggest that CIDE-A (show CIDEA Antibodies) and UCP1 are regulated by insulin (show INS Antibodies) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
uncoupling protein 1 (mitochondrial, proton carrier)
, uncoupling protein 1
, mitochondrial brown fat uncoupling protein 1
, solute carrier family 25 member 7
, UCP 1
, uncoupling protein 1 UCP1
, uncoupling protein 1, mitochondrial
, uncoupling protein, mitochondrial
, mitochondrial, proton carrier
, Solute carrier family 25 member 7