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anti-Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) Antibodies

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP1 Kits (21) and UCP1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UCP1 7350 P25874
UCP1 22227 P12242
UCP1 24860 P04633
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Top anti-UCP1 Antibodies at

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185512 (1 ug/ml) staining of Human Adipose lysate (35 ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged UCP1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Mouse Un-conjugated WB UCP1 monoclonal antibody (M03), clone 4B7. Western Blot analysis of UCP1 expression in NIH/3T3. 50 μg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-UCP-1 Polyclonal Antibody, Unconjugated (ABIN675413) at 1:300 followed by conjugation to the secondary antibody and DAPI staining 100 μL Log in to see 3 to 7 Days
Mouse Rabbit Un-conjugated WB Anti-UCP1 antibody, Western blotting Lane 1: Rat Spleen Tissue Lysate Lane 2: Rat Lung Tissue Lysate Lane 3: Mouse Spleen Tissue Lysate Lane 4: Mouse Lung Tissue Lysate Lane 5: HEPA Cell Lysate 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB Lane 4: Recombinant Human UCP1 Protein 1.25ng 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days

UCP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-UCP1 Antibodies

  1. Human Monoclonal UCP1 Primary Antibody for ELISA, WB - ABIN393398 : Kim, Lee: The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women. in International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2010 (PubMed)
    Show all 5 references for ABIN393398

  2. Human Polyclonal UCP1 Primary Antibody for IF (p), IHC (p) - ABIN675413 : Lu, Ji, Zhang, Zhang, Zhang, An, Liu, Zheng: Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. in Endocrinology 2012 (PubMed)
    Show all 2 references for ABIN675413

  3. Dog (Canine) Polyclonal UCP1 Primary Antibody for WB - ABIN374628 : Ishigaki, Katagiri, Yamada, Ogihara, Imai, Uno, Hasegawa, Gao, Ishihara, Shimosegawa, Sakoda, Asano, Oka: Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. in Diabetes 2005 (PubMed)

More Antibodies against UCP1 Interaction Partners

Arabidopsis thaliana Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.

  2. Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.

  3. Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.

  4. The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]

Pig (Porcine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.

  2. An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.

Human Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. In inguinal white adipose tissue (iWAT) of mice fed a high-fat diet (HFD), Ucp1 level decreases concomitantly with increases in Cnot7 (show CNOT7 Antibodies) and its interacting partner Tob (show TDO2 Antibodies).

  2. Findings suggest that polymorphisms in SIRT6 (show SIRT6 Antibodies)/UCP1 genes may be important for increased carotid plaque burden and echodensity

  3. UCP1 -3826 A>G polymorphism is associated with weight, body fat mass, and risk of type 2 diabetes mellitus in obese individuals candidates for bariatric surgery.

  4. UCP1 and UCP3 (show UCP3 Antibodies) expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery.

  5. this study reveals that human adipose-derived stromal/progenitor cells can be readily differentiated into beige (show LYST Antibodies) adipocytes that, upon activation, undergo uncoupling protein 1-dependent thermogenesis.

  6. This study suggests that the SNP rs1800592 in the UCP1 gene is associated with increased risk of PDR in the Chinese type 2 diabetes mellitus population.

  7. Genotype and allele distributions of UCP1, UCP2 (show UCP2 Antibodies) and UCP3 (show UCP3 Antibodies) polymorphisms did not differ significantly between obese and non-obese Type 2 Diabetes Mellitus patients.[Meta-analysis]

  8. Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.

  9. Meta-analysis. There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences.

  10. By the application of these findings, we demonstrate that UCP1 is functionally thermogenic in intact brite adipocytes and adrenergic UCP1 activation is largely dependent on adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) rather than hormone sensitive lipase (HSL (show LIPE Antibodies)).

Mouse (Murine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. Metabolically inert perfluorinated fatty acids directly activate brown adipose tissue UCP1.

  2. Mice acclimatized to thermoneutrality revealed that Cpt2A-null interscapular brown adipose tissue failed to induce the expression of thermogenic genes such as Ucp1 and Pgc1a (show PPARGC1A Antibodies).

  3. Data show that fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of mitochondrial uncoupling protein 1 (show SLC25A19 Antibodies) (UCP1) and beta3 adrenergic receptor (show ADRB3 Antibodies) (beta3AR).

  4. Skin temperature in the interscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positive control, but not in Cox7a1 (show COX7A1 Antibodies) knockout pups

  5. PKA-dependent IRE1alpha (show ERN1 Antibodies)-XBP1 (show XBP1 Antibodies) activation is crucial for the transcriptional induction of Ucp1 in brown adipocytes.

  6. FGF21 (show FGF21 Antibodies)-mediated improvements in clearance of a glucose challenge require UCP1.

  7. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 (show HDAC1 Antibodies) from promoters of Ucp1/Pgc1a (show PPARGC1A Antibodies), to up-regulation of histone H3 (show HIST3H3 Antibodies) acetylation, to dissociation of polycomb (show CBX2 Antibodies) repressive complexes, and to up-regulation of thermogenesis.

  8. thermogenic mitochondrial reactive oxygen species alter the redox status of cysteine thiols in brown adipose tissue to drive increased respiration, and that Cys253 of UCP1 is a key target

  9. abundance decreased even more in cold-acclimated UCP1 knockout mice

  10. These data indicate that several important metabolic endpoints of FGF21 (show FGF21 Antibodies) are UCP1 independent

Cow (Bovine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (show UCP2 Antibodies) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.

  2. These results suggest that CIDE-A (show CIDEA Antibodies) and UCP1 are regulated by insulin (show INS Antibodies) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.

UCP1 Antigen Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Gene names and symbols associated with UCP1

  • uncoupling family protein PUMP2 (PUMP1) antibody
  • uncoupling protein 1 (mitochondrial, proton carrier) (UCP1) antibody
  • uncoupling protein 1 (UCP1) antibody
  • uncoupling protein 1 (mitochondrial, proton carrier) (ucp1) antibody
  • uncoupling protein 1 (mitochondrial, proton carrier) (Ucp1) antibody
  • AI385626 antibody
  • ATPUMP1 antibody
  • ATUCP1 antibody
  • plant uncoupling mitochondrial protein 1 antibody
  • Slc25a7 antibody
  • Ucp antibody
  • UCP1 antibody
  • Ucpa antibody
  • Uncp antibody

Protein level used designations for UCP1

uncoupling protein 1 (mitochondrial, proton carrier) , uncoupling protein 1 , mitochondrial brown fat uncoupling protein 1 , solute carrier family 25 member 7 , thermogenin , UCP 1 , uncoupling protein 1 UCP1 , uncoupling protein 1, mitochondrial , uncoupling protein, mitochondrial , mitochondrial, proton carrier , Solute carrier family 25 member 7 , Thermogenin

824578 Arabidopsis thaliana
461504 Pan troglodytes
574124 Macaca mulatta
751863 Sus scrofa
100036979 Xenopus laevis
100135179 Xenopus (Silurana) tropicalis
7350 Homo sapiens
403574 Canis lupus familiaris
22227 Mus musculus
24860 Rattus norvegicus
281561 Bos taurus
100328618 Oryctolagus cuniculus
101835783 Mesocricetus auratus
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