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Uroplakin 2 Proteins (UPK2)

UPK2 encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. Additionally we are shipping Uroplakin 2 Antibodies (9) and Uroplakin 2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UPK2 7379 O00526
Mouse UPK2 UPK2 22269  
Rat UPK2 UPK2 689093  
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Top Uroplakin 2 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

UPK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,

Top referenced Uroplakin 2 Proteins

  1. Human Uroplakin 2 Protein expressed in Escherichia coli (E. coli) - ABIN1098745 : Jenkins, Bitner-Glindzicz, Malcolm, Allison, de Bruyn, Flanagan, Thomas, Belk, Feather, Bingham, Southgate, Woolf: Mutation analyses of Uroplakin II in children with renal tract malformations. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006 (PubMed)

More Proteins for Uroplakin 2 (UPK2) Interaction Partners

Human Uroplakin 2 (UPK2) interaction partners

  1. UPII, GATA3, and p40, when used in combination, are highly sensitive in the differential diagnosis of invasive urothelial carcinoma.

  2. UPII was highly specific/moderately sensitive for urothelial carcinoma. May be a potentially useful marker to identify urothelial lineage and help distinguish UC from prostate cancer or, in conjunction with GATA3 (show GATA3 Proteins), from metastatic breast cancer.

  3. UPII demonstrates a significantly higher sensitivity than UPIII (show UPK3A Proteins) in conventional and variant urothelial carcinomas

  4. Uroplakin II antibody BC21 demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III (show UPK3A Proteins), suggesting an advantage in differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.

  5. combination of prostate stem cell antigen (show PSCA Proteins) enhancer and uroplakin II promoter is feasible in constructing bladder cancer-specific vectors

  6. study offers no definitive support for uroplakin II mutations causing human renal tract malformations

Mouse (Murine) Uroplakin 2 (UPK2) interaction partners

  1. The despites a lower level of expression, UPII maintain its plaque association in urothelial preneoplastic lesions.

  2. Bladder-specific autoimmune response sufficient to induce inflammation and interstitial cystitis occurs in mice following immunization with recombinant murine UPK2.

  3. The UPII knockout abolished plaque formation, indicating that both uroplakin heterodimers (UPIa/II and UPIb (show UPK1B Proteins)/III or IIIb) are required for plaque assembly.

Pig (Porcine) Uroplakin 2 (UPK2) interaction partners

  1. HNF4 (show HNF4A Proteins) positively regulates pUPII gene promoter activity.

Uroplakin 2 (UPK2) Protein Profile

Protein Summary

This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.

Gene names and symbols associated with Uroplakin 2 Proteins (UPK2)

  • uroplakin 2 (UPK2)
  • uroplakin 2 (upk2)
  • uroplakin 2 (Upk2)
  • AW491716 protein
  • UP2 protein
  • UPII protein
  • UPK2 protein

Protein level used designations for Uroplakin 2 Proteins (UPK2)

uroplakin 2 , uroplakin II , uroplakin-2 , UP2 , UPII

610673 Canis lupus familiaris
707184 Macaca mulatta
100216448 Xenopus (Silurana) tropicalis
7379 Homo sapiens
22269 Mus musculus
689093 Rattus norvegicus
281569 Bos taurus
397075 Sus scrofa
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