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VIPAR encodes a protein involved in the sorting of lysosomal proteins. Additionally we are shipping VIPAR Antibodies (18) and many more products for this protein.
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Our data suggest that the ARC (show NOL3 Proteins) syndrome may result through impaired VIPAS39/SPE-39 and Vps33b (show VPS33B Proteins)-dependent endosomal maturation or fusion.
VPS16B, similar to its binding partner VPS33B (show VPS33B Proteins), is essential for megakaryocyte and platelet alpha-granule biogenesis.
SPE-39 has an inhibitory effect due to tyrosine phosphorylation and ubiquitination on the function of Vps33B (show VPS33B Proteins) in the EGF (show EGF Proteins)-stimulated cells
SPE-39 homologues are present in RAB5 (show RAB5A Proteins)-, RAB7 (show RAB7B Proteins)-, and RAB11 (show RAB11A Proteins)-positive endosomes where they play a conserved role in lysosomal delivery and probably function via their interaction with the core HOPS (show ALPL Proteins) complex.
The VPS33B (show VPS33B Proteins)-VIPAR complex thus has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney.
This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.
VPS33B interacting protein, apical-basolateral polarity regulator
, vacuolar protein sorting 16 homolog A
, SPE-39 protein
, VPS33B-interacting protein in apical-basolateral polarity regulator
, VPS33B-interacting protein in polarity and apical restriction
, VPS33B-interacting protein involved in polarity and apical protein restriction
, protein spe-39 homolog
, spermatogenesis-defective protein 39 homolog