You are viewing an incomplete version of our website. Please click to reload the website as full version.

Vang-Like 2 (Van Gogh, Drosophila) Proteins (VANGL2)

The protein encoded by VANGL2 is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. Additionally we are shipping VANGL2 Antibodies (67) and VANGL2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse VANGL2 VANGL2 93840 Q91ZD4
VANGL2 57216 Q9ULK5
Rat VANGL2 VANGL2 289229 P84889
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top VANGL2 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

VANGL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) Interaction Partners

Mouse (Murine) Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

  1. Vangl2-regulated polarisation and subsequent acquisition of an epithelial phenotype is essential to lengthen the tubular outflow vessel, a process that is essential for on-going cardiac morphogenesis.

  2. Vangl2 regulates E-cadherin (show CDH1 Proteins) in epithelial cells.

  3. Vangl2 function in podocytes is important for glomerular development and protects against glomerular injury in adult animals.

  4. Vangl1 and Vangl2 may play a key role in the embryo implantation of mice

  5. The first signal, controlled by cadherin, EGF (show EGF Proteins)-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2 (show CELSR2 Proteins), Celsr3 (show CELSR3 Proteins), Frizzled3 (Fzd3 (show FZD3 Proteins)) and Van Gogh like2 (Vangl2) organizes multicilia in individual cells (single-cell polarity)

  6. Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified.

  7. Testin (show TES Proteins) interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.

  8. Apical boundary rearrangement is inhibited in Vangl2 mutant neural epithelium.

  9. Morphological and histological examination of homozygous mouse embryos revealed a neural tube closure defect that leads to craniorachischis ...Vangl2(m1Yzcm) may be a loss-of-function mutant.

  10. Changed auditory hair cell planar polarity in the Vangl2 KO mice leads to hearing deficits.

Zebrafish Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

  1. dynamic Vangl2 intracellular distribution is coordinated with and necessary for the changes in convergence and extension cell behaviors during gastrulation

  2. we found that the critical period for Vangl2 function coincides with the initial stages of FBM neuron migration out of rhombomere 4.

  3. Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function

  4. VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase.

  5. Vangl2(R259L) behaved like the wild-type allele in overexpression and morpholino knockdown/rescue assays in zebrafish embryos.

  6. Rack1 (show GNB2L1 Proteins) has a dominant-negative effect on Vangl2 localization and gastrulation.

  7. data suggest that bbs8 (show TTC8 Proteins) and vangl2 act synergistically on cell polarization to establish and maintain the appropriate length and number of cilia in the Kupffer's vesicle and thereby facilitate correct LR asymmetry

  8. Vangl2 is required for asymmetric localization and posterior tilting of primary motile cilia at the apical membrane of epithelial cells.

  9. show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain

  10. The vangl2 gene product mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis.

Human Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

  1. VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1 (show SQSTM1 Proteins)-JNK (show MAPK8 Proteins) pathway.

  2. Propose that Arfrp1 (show ARFRP1 Proteins) exposes a binding site on AP-1 (show FOSB Proteins) that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell.

  3. The aberrant VANGL2 promoter methylation and the decreased gene expression is associated with Tetralogy of Fallot.

  4. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT (show WNT2 Proteins)/planar cell polarity pathway.

  5. Van-Gogh-like 2 is frequently methylated in MSI (show MSI1 Proteins)-CRCs with BRAF (show BRAF Proteins) mutation and may act as a tumour suppressor gene, counteracting WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  6. these findings strongly implicate VANGL2 in the genetic causation of spinal NTDs in a subset of patients and provide additional evidence for a pathogenic role of PCP (show PRCP Proteins) signaling in these malformations.

  7. Loss of membrane targeting of Vangl1 and Vangl2 proteins causes neural tube defects.

  8. The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.

  9. Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase (show MMP20 Proteins)-dependent invasion.

  10. Results suggest that there is no specific mutation responsible for the Tetralogy of Fallot phenotype in the Vangl2 gene [Vangl2].

VANGL2 Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.

Gene names and symbols associated with VANGL2

  • vang-like 2 (van gogh, Drosophila) (VANGL2)
  • VANGL planar cell polarity protein 2 (vangl2)
  • vang-like 2 (LOC100354291)
  • vang-like 2 (van gogh, Drosophila) (Vangl2)
  • vang-like 2 (van gogh, Drosophila) (vangl2)
  • VANGL planar cell polarity protein 2 (VANGL2)
  • VANGL planar cell polarity protein 2 (Vangl2)
  • C530001F03Rik protein
  • loop-tail protein
  • Lp protein
  • LPP1 protein
  • LTAP protein
  • ska17 protein
  • ska protein
  • STB1 protein
  • STBM protein
  • STBM1 protein
  • strabismus protein
  • tri protein
  • vang protein
  • Vang1l2 protein
  • VANGL2 protein

Protein level used designations for VANGL2

vang-like 2 (van gogh, Drosophila) , Van Gogh , protein strabismus , van Gogh-like protein 2 , vang-like protein 2 , vang-like 2 , loop tail associated protein , loop-tail protein 1 , loop-tail-associated protein , vang (van gogh)-like 2 , protein trilobite , strabismus , trilobite , loop-tail protein 1 homolog , strabismus 1

610037 Canis lupus familiaris
426903 Gallus gallus
613073 Xenopus (Silurana) tropicalis
720239 Macaca mulatta
100354291 Oryctolagus cuniculus
93840 Mus musculus
245949 Danio rerio
520544 Bos taurus
57216 Homo sapiens
289229 Rattus norvegicus
Selected quality suppliers for VANGL2 Proteins (VANGL2)
Did you look for something else?