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May act as a specific coactivator for the mammalian TEFs (By similarity).. Additionally we are shipping Vestigial Like 4 (Drosophila) Antibodies (40) and many more products for this protein.
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VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia.
The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling pathway in gastric cancer.
our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.
VGLL4 directly competes with YAP (show YAP1 Proteins) in binding to TEADs and executes its growth-inhibitory function through two TDU (show VGLL1 Proteins) domains.
rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa.
This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process.
Loss of VGLL4 expression is associated with gastric cancer.
Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments.
IRF2BP2 was identifies as a novel VGLL4 partner.
This gene is named Vestigial-like 4, (show TEAD1 Proteins)to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors.
Vgl-4 modulates the activity of TEF-1 (show TEAD1 Proteins) factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes
May act as a specific coactivator for the mammalian TEFs (By similarity).
transcription cofactor vestigial-like protein 4
, Vestigial-like 4