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Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) ELISA Kits

Vitamin K is essential for blood clotting but must be enzymatically activated. Additionally we are shipping VKORC1 Antibodies (26) and VKORC1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
VKORC1 79001 Q9BQB6
VKORC1 27973 Q9CRC0
VKORC1 309004 Q6TEK4
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Top VKORC1 ELISA Kits at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.57 ng/mL 1.56-100 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Cow 0.78-50 ng/mL   96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for VKORC1 Interaction Partners

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. Genetic variants of CYP2C9 (show CYP2C9 ELISA Kits)/VKORC1 and age are significant determinants of the maintenance dose of warfarin in patients with atrial fibrillation/valve replacement.

  2. The Arg98Trp mutation disrupts an ER retention motif of VKORC1 leading to mislocalisation of the protein to outside the endoplasmatic reticulum. In this review, we summarize the clinical data, diagnosis, therapy and molecular pathomechanism of VKCFD2.

  3. Possession of CYP2C9 (show CYP2C9 ELISA Kits)*2 and/or CYP2C9 (show CYP2C9 ELISA Kits)*3 allele variants is associated with lower time of international normalized ratio (INR (show INSR ELISA Kits)) in the therapeutic range (TTR (show TTR ELISA Kits)) values and warfarin dose variations in aortic valve replacement patients, the latter affected also by VKORC1 c.-1693G>A polymorphism

  4. Three SNPs (CYP2C9 (show CYP2C9 ELISA Kits) *2, *3 and VKORC1 c.-1639G > A) were genotyped by electrochemical detection using a sandwich-type format that included a 3' short thiol capture probe and a 5' ferrocene-labeled signal probe.

  5. Our results show that anticoagulated patients have a high risk of adverse events if they are carriers of 1 or more genetic polymorphisms in the VKORC1 (rs9923231) and CYP2C9 (show CYP2C9 ELISA Kits) (rs1799853 and rs1057910) genes.

  6. The VKORC1 (-1693 G>A) AA genotype was associated with fewer cases of DVT (odds ratio = 0.435; 95% confidence interval 0.205-0.991; P = .031).

  7. This study provides data on VKORC1 and CYP4F2 variants among an indigenous Ghanaian population. In a multivariate analysis, duration of Ghanaian patients on warfarin therapy and VKORC1 gene was associated with warfarin dose classification.

  8. Obtained results suggested that VKORC1 -1639A allele can be a possible genetic risk factor for IS in Ukrainian population.

  9. VKORC1-CYP2C9 (show CYP2C9 ELISA Kits) interaction can affect warfarin stable dosage.

  10. VKORC1S1639 GG and the wild type CYP2C9 (show CYP2C9 ELISA Kits)*1*1genotypes are associated with the high-dose requirement for warfarin therapy.

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. quantified mRNA levels for VKORC1, VKORC1L1, GGCX (show GGCX ELISA Kits), and NQO1 (show NQO1 ELISA Kits) and measured VKOR enzymatic activities in 29 different tissues

  2. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX ELISA Kits)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  3. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.

  4. molecular cloning [VKORC1]

  5. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.

  6. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.

  7. Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

VKORC1 Antigen Profile

Antigen Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

  • vitamin K epoxide reductase complex, subunit 1 (VKORC1) antibody
  • vitamin K epoxide reductase complex subunit 1 (vkorc1) antibody
  • vitamin K epoxide reductase complex, subunit 1 (vkorc1) antibody
  • Vitamin-K epoxide reductase (Vkor) antibody
  • vitamin K epoxide reductase complex, subunit 1 (Vkorc1) antibody
  • BP1071 antibody
  • CG33544 antibody
  • D7Wsu86e antibody
  • Dmel\\CG33544 antibody
  • EDTP308 antibody
  • HDC06808 antibody
  • IMAGE3455200 antibody
  • MGC89620 antibody
  • MST134 antibody
  • MST576 antibody
  • VKCFD2 antibody
  • VKOR antibody
  • VKORC1 antibody

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID SPECIES
404205 Gallus gallus
446034 Takifugu rubripes
448775 Xenopus (Silurana) tropicalis
479775 Canis lupus familiaris
3346188 Drosophila melanogaster
79001 Homo sapiens
27973 Mus musculus
309004 Rattus norvegicus
445422 Bos taurus
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