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WDR5 encodes a member of the WD repeat protein family. Additionally we are shipping WDR5 Antibodies (99) and many more products for this protein.
Showing 10 out of 13 products:
Human WDR5 Protein expressed in Wheat germ - ABIN1325241
Sathi, Tsujigiwa, Ito, Siar, Katase, Tamamura, Harada, Nagatsuka: Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma. in Oral surgery, oral medicine, oral pathology and oral radiology 2012
we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (show MSH2 Proteins) gene expression.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (show MYC Proteins), also found to interact with WDR5.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (show KAT2A Proteins) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
WDR5 shows a direct binding to the ZNF407 promoter.
Taken together, these data suggest that WDR5 is directly involved in p53 (show TP53 Proteins) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
WDR5 over-expression is associated with poor breast cancer clinical outcome.
Results identify WDR5 as a key cofactor for N-Myc (show MYCN Proteins)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (show MYCN Proteins)-amplified neuroblastomas.
BIG3 may block the KPNAs (KPNA1 (show KPNA1 Proteins), KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2 (show PHB2 Proteins).
solution structures of the MLL3 core complex assembled with and without WDR5 by small angle x-ray scattering show similar overall topologies
Cbx8 (show CBX8 Proteins) associates with non-PRC1 (show PRC1 Proteins) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (show NOTCH1 Proteins) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (show IL1B Proteins), and TNFalpha (show TNF Proteins) induced chemokine (show CCL1 Proteins) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (show MLL Proteins) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (show MYC Proteins) with chromatin depends on interaction with the WD40 (show DCAF12L2 Proteins)-repeat protein WDR5.
BIG3 inhibits insulin (show INS Proteins) granule biogenesis and insulin (show INS Proteins) secretion.
BIG3 negatively regulates insulin (show INS Proteins) granule exocytosis by restricting insulin (show INS Proteins) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (show KAT2B Proteins) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (show DYM Proteins)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (show MLLT1 Proteins) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (show RBBP5 Proteins) through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Proteins) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WD repeat domain 5
, WD repeat-containing protein 5
, BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD-repeat protein 5
, WD repeat-containing protein BIG-3