WD Repeat Domain 5 Proteins (WDR5)

WDR5 encodes a member of the WD repeat protein family. Additionally we are shipping WDR5 Antibodies (99) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WDR5 11091 P61964
WDR5 140858 P61965
WDR5 362093 Q498M4
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Top WDR5 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days

WDR5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)
Rat (Rattus) ,

Top referenced WDR5 Proteins

  1. Human WDR5 Protein expressed in Wheat germ - ABIN1325241 : Sathi, Tsujigiwa, Ito, Siar, Katase, Tamamura, Harada, Nagatsuka: Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma. in Oral surgery, oral medicine, oral pathology and oral radiology 2012 (PubMed)

More Proteins for WD Repeat Domain 5 (WDR5) Interaction Partners

Xenopus laevis WD Repeat Domain 5 (WDR5) interaction partners

  1. we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  2. The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (show MSH2 Proteins) gene expression.

Human WD Repeat Domain 5 (WDR5) interaction partners

  1. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis

  2. WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (show MYC Proteins), also found to interact with WDR5.

  3. This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (show KAT2A Proteins) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.

  4. WDR5 shows a direct binding to the ZNF407 promoter.

  5. Taken together, these data suggest that WDR5 is directly involved in p53 (show TP53 Proteins) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.

  6. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

  7. WDR5 over-expression is associated with poor breast cancer clinical outcome.

  8. Results identify WDR5 as a key cofactor for N-Myc (show MYCN Proteins)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (show MYCN Proteins)-amplified neuroblastomas.

  9. BIG3 may block the KPNAs (KPNA1 (show KPNA1 Proteins), KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2 (show PHB2 Proteins).

  10. solution structures of the MLL3 core complex assembled with and without WDR5 by small angle x-ray scattering show similar overall topologies

Mouse (Murine) WD Repeat Domain 5 (WDR5) interaction partners

  1. Cbx8 (show CBX8 Proteins) associates with non-PRC1 (show PRC1 Proteins) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (show NOTCH1 Proteins) gene expression.

  2. Wdr5 suppression also reduced IFNgamma, Il-1beta (show IL1B Proteins), and TNFalpha (show TNF Proteins) induced chemokine (show CCL1 Proteins) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis

  3. results suggest that specific RNAs are integral inputs into the WDR5-MLL (show MLL Proteins) complex for maintenance of the active chromatin state and embryonic stem cell fates

  4. Data show that broad association of myc proto-oncogene protein MYC (show MYC Proteins) with chromatin depends on interaction with the WD40 (show DCAF12L2 Proteins)-repeat protein WDR5.

  5. BIG3 inhibits insulin (show INS Proteins) granule biogenesis and insulin (show INS Proteins) secretion.

  6. BIG3 negatively regulates insulin (show INS Proteins) granule exocytosis by restricting insulin (show INS Proteins) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.

  7. Depletion of KAT2B (show KAT2B Proteins) or WDR5 decreased gluconeogenic gene expression.

  8. analysis of a novel mechanism for epigenetic control of SMC (show DYM Proteins)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes

  9. Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (show MLLT1 Proteins) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.

  10. Characterization of a novel WDR5-binding site that recruits RbBP5 (show RBBP5 Proteins) through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Proteins) lysine 4 by mixed lineage leukemia protein-1.

WDR5 Protein Profile

Protein Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with WD Repeat Domain 5 Proteins (WDR5)

  • WD repeat domain 5 (wdr5)
  • WD repeat domain 5 L homeolog (wdr5.L)
  • WD repeat domain 5 S homeolog (wdr5.S)
  • WD repeat domain 5 (WDR5)
  • WD repeat domain 5 (Wdr5)
  • 2410008O07Rik protein
  • AA408785 protein
  • AA960360 protein
  • Big protein
  • Big-3 protein
  • MGC80538 protein
  • MGC81485 protein
  • SWD3 protein
  • wdr5-a protein
  • wdr5-b protein
  • wu:fk47f04 protein
  • xwdr5 protein
  • zgc:56591 protein
  • zgc:76895 protein

Protein level used designations for WD Repeat Domain 5 Proteins (WDR5)

WD repeat domain 5 , WD repeat-containing protein 5 , BMP2-induced 3-kb gene protein , SWD3, Set1c WD40 repeat protein, homolog , WD-repeat protein 5 , WD repeat-containing protein BIG-3

406372 Danio rerio
446809 Xenopus laevis
447447 Xenopus laevis
496891 Xenopus (Silurana) tropicalis
11091 Homo sapiens
140858 Mus musculus
362093 Rattus norvegicus
100125836 Bos taurus
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