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TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]\; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010].. Additionally we are shipping WDR82 Antibodies (10) and WDR82 Kits (2) and many more products for this protein.
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these findings demonstrate that WDR82 is a negative regulator of virus-triggered type I IFNs pathway through mediating TRAF3 (show TRAF3 Proteins) polyubiquitination status and stability on mitochondria.
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 (show PPA1 Proteins) phosphatase complex (PNUTS (show PPP1R10 Proteins), Tox4, Wdr82, PP1 (show PPA1 Proteins)) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
suggest a model for how the mammalian RNA polymerase II machinery is linked with histone H3 (show HIST3H3 Proteins)-Lys4 histone methyltransferase complexes at transcriptionally active genes
Data show that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes.
the result of a blocked WDR82 consists of stunted embryonic development and death. Thus, WDR82 can be considered a key epigenetic regulation-related factor crucial in the normal growth and development of embryos.
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005
WD repeat-containing protein 82
, transmembrane protein 113
, WD repeat domain 82 pseudogene 1
, protein word of mouth
, word of mouth