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WNK Lysine Deficient Protein Kinase 1 Proteins (WNK1)

WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Additionally we are shipping WNK1 Antibodies (121) and WNK1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WNK1 65125 Q9H4A3
Mouse WNK1 WNK1 232341 P83741
Rat WNK1 WNK1 116477 Q9JIH7
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Top WNK1 Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
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WNK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaction Partners

Horse (Equine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Chimpanzee WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Xenopus laevis WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Zebrafish WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. wnk1 is a downstream target for Vegfr2 (vascular endothelial growth factor receptor-2 (show KDR Proteins)) and Akt (show AKT1 Proteins)/PI3K signaling and thereby affects angiogenesis in zebrafish embryos.

  2. loss-of-function mutation in WNK1 induces an overexpression of KCC2 (show SLC12A5 Proteins) and hinders proper peripheral sensory nerve development, a hallmark of HSANII

Rhesus Monkey WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Human WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. Single nucleotide polymorphisms STK39 (show STK39 Proteins) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study

  2. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (show SLC12A5 Proteins) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  3. Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.

  4. a novel gene, WNK1, for susceptibility to pelvic organ prolapse

  5. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (show NEDD4L Proteins) substrate, thereby linking aldosterone and other NEDD4-2 (show NEDD4L Proteins)-suppressing antinatriuretic hormones to NCC (show SLC12A3 Proteins) phosphorylation status.

  6. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  7. conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension

  8. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OXSR1 Proteins) and SPAK (show STK39 Proteins) in mediating proliferation, invasion, and gene expression in endothelial cells

  9. Report generation of WNK1 knockout cell lines and effects on WNK signaling.

  10. data suggest that WNK1 functions as a chloride sensor through direct binding of a regulatory chloride ion to the active site, which inhibits autophosphorylation

Mouse (Murine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel (show KCNMA1 Proteins) expression and K(+) secretion in collecting ducts.

  2. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (show SLC12A5 Proteins) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  3. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (show NEDD4L Proteins) substrate, thereby linking aldosterone and other NEDD4-2 (show NEDD4L Proteins)-suppressing antinatriuretic hormones to NCC (show SLC12A3 Proteins) phosphorylation status.

  4. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  5. increased protein expression levels of WNK1 and WNK4 (show WNK4 Proteins) kinases cause PHAII by KLHL3 (show KLHL3 Proteins) R528H mutation due to impaired KLHL3 (show KLHL3 Proteins)-Cullin3-mediated ubiquitination.

  6. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OSR1 Proteins) and SPAK (show STK39 Proteins) in mediating proliferation, invasion, and gene expression in endothelial cells

  7. WNK1 stimulates the activity of the Na-Cl cotransporter (show SLC12A3 Proteins) via SPAK (show STK39 Proteins), an effect antagonized by WNK4 (show WNK4 Proteins).

  8. Results show that the expression profiles of Wnk1 isoforms change during the development, and that the expression of the Wnk1 splice variant containing the Hsn2 exon is prominent during developing and in adult mouse tissues.

  9. subset of integral membrane proteins, therefore, requires an early dislocation event to expose part of their luminal domain to the cytosol, before HRD1 (show SYVN1 Proteins)-mediated polyubiquitination and dislocation

  10. In Wnk1 knockout mice, levels of Lhx8 (show LHX8 Proteins) expression were reduced, inhibiting neural specification.

Pig (Porcine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

WNK1 Protein Profile

Protein Summary

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

Gene names and symbols associated with WNK1

  • WNK lysine deficient protein kinase 1 (WNK1)
  • WNK lysine deficient protein kinase 1 (wnk1.3)
  • WNK lysine deficient protein kinase 1b (wnk1b)
  • WNK lysine deficient protein kinase 1 (wnk1.2)
  • WNK lysine deficient protein kinase 1 (wnk1)
  • WNK lysine deficient protein kinase 1 (LOC100350906)
  • serine/threonine-protein kinase WNK1 (WNK1)
  • WNK lysine deficient protein kinase 1 (Wnk1)
  • 6430573H23Rik protein
  • ATWNK1 protein
  • EG406236 protein
  • fc14f06 protein
  • HSAN2 protein
  • Hsn2 protein
  • KDP protein
  • mKIAA0344 protein
  • p65 protein
  • pha2c protein
  • Prkwnk1 protein
  • PSK protein
  • si:ch211-240l19.1 protein
  • T9J14.14 protein
  • T9J14_14 protein
  • with no lysine (K) kinase 1 protein
  • wnk1 protein
  • wu:fc14f06 protein
  • ZIK4 protein

Protein level used designations for WNK1

WNK lysine deficient protein kinase 1 , serine/threonine-protein kinase WNK1-like , WNK lysine deficient protein kinase 1 isoform , erythrocyte 65 kDa protein , prostate-derived sterile 20-like kinase , protein kinase with no lysine 1 , serine/threonine-protein kinase WNK1 , protein kinase lysine-deficient 1

GENE ID SPECIES
100056745 Equus caballus
451739 Pan troglodytes
496095 Xenopus laevis
561159 Danio rerio
706493 Macaca mulatta
733420 Xenopus laevis
734160 Xenopus laevis
100017207 Monodelphis domestica
100036683 Xenopus (Silurana) tropicalis
100350906 Oryctolagus cuniculus
100436057 Pongo abelii
100594288 Nomascus leucogenys
819651 Arabidopsis thaliana
65125 Homo sapiens
232341 Mus musculus
116477 Rattus norvegicus
477728 Canis lupus familiaris
406235 Sus scrofa
506433 Bos taurus
427925 Gallus gallus
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