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The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Additionally we are shipping WW and C2 Domain Containing 1 Kits (11) and WW and C2 Domain Containing 1 Proteins (6) and many more products for this protein.
Showing 10 out of 49 products:
Human Polyclonal WWC1 Primary Antibody for ICC, IF - ABIN4328780
Tanaka, Osada, Fujii, Fukatsu, Hida, Horio, Kondo, Sato, Hasegawa, Tsujimura, Sekido: LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. in Oncogene 2015
Merlin (show NF2 Antibodies) and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.
Kibra, a binding partner of Pez (show PTPN14 Antibodies), stabilizes Pez (show PTPN14 Antibodies) via WW-PY/PPxY interaction.
Kibra regulates starvation-induced autophagy downstream of aPKC.
In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.
The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
Kibra functions as a tumor suppressor protein (show TP53 Antibodies) that regulates Hippo signaling in conjunction with Merlin (show NF2 Antibodies) and Expanded.
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Kibra predominantly acts in the Merlin (show NF2 Antibodies) branch upstream of the core kinase cascade to regulate Hippo signaling.
Ability to navigate in the wilderness benefits from episodic memory (KIBRA).
Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3 (show CELSR3 Antibodies)), NIPBL (show NIPBL Antibodies) (Nipped (show RPL38 Antibodies)-B-like), and FN1 (fibronectin 1 (show FN1 Antibodies)).
study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease
show that KIBRA is overexpressed in human prostate tumors. Our studies uncover unexpected results and identify KIBRA as a tumor promoter in prostate cancer
No significant differences in allelic or gene frequency distribution of KIBRA SNP rs17070145 were observed between schizophrenic and healthy control groups.
WWC1 variants are involved in AMPA (show GRIA3 Antibodies) receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.
Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2 (show CA2 Antibodies)/3 and CA4 (show CA4 Antibodies)/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers
decreased expression of the KIBRA gene on both mRNA and protein levels in depression, is reported.
Phosphorylation-dependent regulation of the DNA damage response of Kibra protein in cancer cells
Study did not find support for an association of KIBRA either alone or in combination with CLSTN2 (show CLSTN2 Antibodies) with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in older adults
KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.
KIBRA associates with and activates Lats (large tumor suppressor (show LATS1 Antibodies)) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif
KIBRA functions in memory performance via interaction with PKMzeta.
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.
, lethal (3) neo42
, HBeAg-binding protein 3
, WW, C2 and coiled-coil domain containing 1
, kidney and brain protein
, protein KIBRA
, protein WWC1
, WW domain-containing protein 1