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WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. Additionally we are shipping WHSC1L1 Proteins (4) and many more products for this protein.
Showing 10 out of 82 products:
Polyclonal WHSC1L1 Primary Antibody for WB - ABIN540242
Angrand, Apiou, Stewart, Dutrillaux, Losson, Chambon: NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. in Genomics 2001
Show all 2 Pubmed References
Polyclonal WHSC1L1 Primary Antibody for WB - ABIN540244
Stec, Nagl, van Ommen, den Dunnen: The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? in FEBS letters 2000
Show all 2 Pubmed References
Human Polyclonal WHSC1L1 Primary Antibody for WB - ABIN316304
Yang, Liu, Bollig-Fischer, Giroux, Ethier: Transforming properties of 8p11-12 amplified genes in human breast cancer. in Cancer research 2010
This study demonstrates that over-expression of WHSC1L1 is linked to over-expression of ER-alpha (show ESR1 Antibodies) in SUM-44 breast cancer cells and in primary human breast cancers.
Studies indicate that the NSD methyltransferases NSD1 (show NSD1 Antibodies), NSD2/WHSC1/MMSET (show WHSC1 Antibodies) and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
Results demonstrate that the AML (show RUNX1 Antibodies) maintenance function of BRD4 (show BRD4 Antibodies) requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 (show BRD4 Antibodies) to the CHD8 (show CHD8 Antibodies) chromatin remodeler.
The results describe the binding of NSD1 (show NSD1 Antibodies), 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.
The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target.
PPAPDC1B (show PPAPDC1B Antibodies) and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.
Data indicate that siRNA attenuated the expression levels of CCNG1 (show CCNG1 Antibodies) and NEK7 (show NEK7 Antibodies), implying that WHSC1L1 appears to activate the expression of CCNG1 (show CCNG1 Antibodies) and NEK7 (show NEK7 Antibodies) in cancer cells.
methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 (show HIST3H3 Antibodies) recognition
Functional studies with Brd4 (show BRD4 Antibodies) indicate that the ET domain mediates pTEFb (show CDK9 Antibodies)-independent transcriptional activation through a subset of these associated factors, including NSD3.
Overexpression of WHSC1L1 gene is associated with breast cancer.
This study reveals a critical role of NSD3-mediated IRF3 (show IRF3 Antibodies) methylation in enhancing antiviral innate immunity.
WHSC1L1-L acts as a histone methyltransferase in podocytes and regulates nephrin (show NPHS1 Antibodies) gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
histone-lysine N-methyltransferase NSD3
, Wolf-Hirschhorn syndrome candidate 1-like 1
, histone-lysine N-methyltransferase NSD3-like
, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine
, WHSC1-like protein 1
, nuclear SET domain-containing protein 3
, protein whistle
, wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog