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WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. Additionally we are shipping WHSC1L1 Antibodies (85) and many more products for this protein.
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Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET (show WHSC1 Proteins) and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
Results demonstrate that the AML maintenance function of BRD4 requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler.
The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.
The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target.
PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.
Data indicate that siRNA attenuated the expression levels of CCNG1 (show CCNG1 Proteins) and NEK7 (show NEK7 Proteins), implying that WHSC1L1 appears to activate the expression of CCNG1 (show CCNG1 Proteins) and NEK7 (show NEK7 Proteins) in cancer cells.
methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 (show HIST3H3 Proteins) recognition
Functional studies with Brd4 (show BRD4 Proteins) indicate that the ET domain mediates pTEFb (show CDK9 Proteins)-independent transcriptional activation through a subset of these associated factors, including NSD3.
Overexpression of WHSC1L1 gene is associated with breast cancer.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
histone-lysine N-methyltransferase NSD3
, Wolf-Hirschhorn syndrome candidate 1-like 1
, histone-lysine N-methyltransferase NSD3-like
, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine
, WHSC1-like protein 1
, nuclear SET domain-containing protein 3
, protein whistle
, wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog