Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by XPNPEP3 belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. Additionally we are shipping X-Prolyl Aminopeptidase (Aminopeptidase P) 3, Putative Proteins (6) and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal XPNPEP3 Primary Antibody for ICC, IF - ABIN4366432
OToole, Liu, Davis, Westlake, Attanasio, Otto, Seelow, Nurnberg, Becker, Nuutinen, Kärppä, Ignatius, Uusimaa, Pakanen, Jaakkola, van den Heuvel, Fehrenbach, Wiggins, Goyal, Zhou, Wolf, Wise, Helou et al.: Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. ... in The Journal of clinical investigation 2010
Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (show NFS1 Antibodies) (mitochondrial cysteine desulfurase (show NFS1 Antibodies)) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55]
The findings reveal that APP3m is a new member of the TNF (show TNF Antibodies)-TNFR2 (show TNFRSF1B Antibodies) signaling complex and characterize an APP3-mediated TNFR2 (show TNFRSF1B Antibodies) signal transduction mechanism that induces activation of JNK1 (show MAPK8 Antibodies) and JNK2 (show MAPK9 Antibodies).
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein (show COX6B2 Antibodies), develop a nephronophthisis-like nephropathy.
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
, X-Pro aminopeptidase 3
, probable Xaa-Pro aminopeptidase 3
, aminopeptidase P3