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XiAP Associated Factor 1 Proteins (XAF1)

XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (90) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
XAF1 54739 Q6GPH4
Mouse XAF1 XAF1 327959 Q5NBU8
Rat XAF1 XAF1 679600  
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Top XAF1 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days

XAF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for XiAP Associated Factor 1 (XAF1) Interaction Partners

Human XiAP Associated Factor 1 (XAF1) interaction partners

  1. SHC1 (show SHC1 Proteins) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.

  2. Our study identified a novel splice variant of XAF1 in cancer cells

  3. Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.

  4. Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.

  5. Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin.

  6. XAF1 stimulates HIPK2 (show HIPK2 Proteins)-mediated Ser (show SIGLEC1 Proteins)-46 phosphorylation of p53 (show TP53 Proteins) and XAF1 also steps up the termination of p53 (show TP53 Proteins)-mediated cell-cycle arrest by activating ZNF313 (show RNF114 Proteins).

  7. XAF1 as a possible sarcoidosis risk gene

  8. Transcriptionally active p73 (show TP73 Proteins) induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma (show BBC3 Proteins) and promotes Bax (show BAX Proteins) translocation during melphalan-induced apoptosis.

  9. Promoter methylation of the XAF1 gene plays an important role in the carcinogenesis and progression of papillary thyroid carcinoma.

  10. Missense polymorphisms in XIAP-associated factor-1 is associated with papillary thyroid cancer.

Mouse (Murine) XiAP Associated Factor 1 (XAF1) interaction partners

  1. Interferon gamma (show IFNG Proteins) induces XAF1 and Noxa (show PMAIP1 Proteins) expression and potentiates apoptosis by STAT3 (show STAT3 Proteins) activation

  2. XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 Proteins), Ang-1 (show ANGPT1 Proteins), Ang-2 (show ANGPT2 Proteins) and c-Myc (show MYC Proteins) may be mechanistically responsible for the observed antiangiogenesis effect.

XAF1 Protein Profile

Protein Summary

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with XAF1

  • zgc:153893 (zgc:153893)
  • XIAP associated factor 1 (XAF1)
  • XIAP associated factor 1 (Xaf1)
  • XIAP associated factor-1 (XAF1)
  • BIRC4BP protein
  • Fbxo39 protein
  • HSXIAPAF1 protein
  • XIAPAF1 protein

Protein level used designations for XAF1

XIAP-associated factor 1 , BIRC4 binding protein , BIRC4-binding protein , F-box protein 39 , novel TRAF-type zinc finger protein

767709 Danio rerio
54739 Homo sapiens
327959 Mus musculus
509740 Bos taurus
679600 Rattus norvegicus
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