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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (90) and many more products for this protein.
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SHC1 (show SHC1 Proteins) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.
Our study identified a novel splice variant of XAF1 in cancer cells
Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.
Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.
Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin.
XAF1 stimulates HIPK2 (show HIPK2 Proteins)-mediated Ser (show SIGLEC1 Proteins)-46 phosphorylation of p53 (show TP53 Proteins) and XAF1 also steps up the termination of p53 (show TP53 Proteins)-mediated cell-cycle arrest by activating ZNF313 (show RNF114 Proteins).
XAF1 as a possible sarcoidosis risk gene
Transcriptionally active p73 (show TP73 Proteins) induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma (show BBC3 Proteins) and promotes Bax (show BAX Proteins) translocation during melphalan-induced apoptosis.
Promoter methylation of the XAF1 gene plays an important role in the carcinogenesis and progression of papillary thyroid carcinoma.
Missense polymorphisms in XIAP-associated factor-1 is associated with papillary thyroid cancer.
Interferon gamma (show IFNG Proteins) induces XAF1 and Noxa (show PMAIP1 Proteins) expression and potentiates apoptosis by STAT3 (show STAT3 Proteins) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 Proteins), Ang-1 (show ANGPT1 Proteins), Ang-2 (show ANGPT2 Proteins) and c-Myc (show MYC Proteins) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein