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ZBP1 encodes a Z-DNA binding protein. Additionally we are shipping Z-DNA Binding Protein 1 Kits (13) and Z-DNA Binding Protein 1 Proteins (10) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal ZBP1 Primary Antibody for ELISA, WB - ABIN1003496
Schwartz, Behlke, Lowenhaupt, Heinemann, Rich: Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. in Nature structural biology 2001
Show all 3 references for ABIN1003496
Human Monoclonal ZBP1 Primary Antibody for FACS - ABIN2666378
Deigendesch, Koch-Nolte, Rothenburg: ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains. in Nucleic acids research 2006
Show all 3 references for ABIN2666378
Human Polyclonal ZBP1 Primary Antibody for WB - ABIN2774646
Rothenburg, Schwartz, Koch-Nolte, Haag: Complex regulation of the human gene for the Z-DNA binding protein DLM-1. in Nucleic acids research 2002
These results indicate that DAI is an important immuno-regulator of the porcine innate immune system
Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host.
DAI could function as a DNA sensor and a regulator in DNA-induced macrophage M2b polarization and lupus nephritis.
Collectively, these results demonstrate that DAI can suppress HSV-1 growth independent of DNA sensing through mechanisms involving suppression of viral genomes and regulation of ICP0.
these data indicate that ZBP1 (show IGF2BP1 Antibodies) may function as an adapter to export the Ro/Y3 RNA complex from nuclei.
Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B (show TDO2 Antibodies)- and Z-DNAs.
hZbeta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism.
These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-kappaB (show NFKB1 Antibodies) pathway.
identify ZBP1 (show IGF2BP1 Antibodies) as being essential for IRF3 (show IRF3 Antibodies) activation and interferon beta (show IFNB1 Antibodies) expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon (show IFNA Antibodies) transcription and secretion.
Z-DNA binding activities of two Zalpha domains in the human ZBP1 (show IGF2BP1 Antibodies), hZalpha(ZBP1 (show IGF2BP1 Antibodies)) and hZbeta(ZBP1 (show IGF2BP1 Antibodies))were characterized.
In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1 (show IGF2BP1 Antibodies).
findings identify ZBP1 as a critical mediator of inflammation beyond its previously known role in antiviral defence and suggest that ZBP1 might be implicated in the pathogenesis of necroptosis-associated inflammatory diseases
findings indicate that the RHIM of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development
DAI as an important cytosolic DNA sensor, is responsible for the recognition of A/T or G/C-rich DNA derived from DNA virus.
Disruption of the in vivo interaction of KIF11 (show KIF11 Antibodies) with ZBP1 delocalizes beta-actin (show ACTB Antibodies) mRNA and affects cell migration.
Association of ribosomes and ZBP1 with the mRNA were anti-correlated both near the nucleus of primary fibroblasts and neurons and in peripheral cellular regions such as the leading edge of fibroblasts, therefore validating the hypothesis that ZBP1 spatially regulates beta-actin (show ACTB Antibodies) mRNA localized translation.
DAI interacts with RIP3 (show MPRIP Antibodies) to mediate virus-induced necrosis analogous to the RIP1 (show RALBP1 Antibodies)-RIP3 (show MPRIP Antibodies) complex controlling death receptor-induced necroptosis.
data support a direct role for ZBP1 in transport and translation of mRNA cargos in axonal regeneration in vitro and in vivo
observations underscore an integral role of DAI (DLM-1/ZBP1) in the DNA-mediated activation of innate immune responses
mechanism of DAI activation and the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses.
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Z-DNA binding protein 1
, tumor stroma and activated macrophage protein DLM-1
, DNA-dependent activator of IFN-regulatory factor
, Z-DNA-binding protein 1
, B-actin zipcode-binding protein 1
, IGF-II mRNA-binding protein 1
, IGF2 mRNA-binding protein 1
, VICKZ family member 1
, insulin-like growth factor 2 binding protein 1
, insulin-like growth factor 2 mRNA-binding protein 1
, insulin-like growth factor 2, binding protein 1
, zipcode-binding protein-1
, DNA-dependent activator of IFN-regulatory factors
, DNA-dependent activator of IRFs
, DNA-dependent activator of interferon regulatory factors