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Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Additionally we are shipping ZC3HC1 Proteins (5) and ZC3HC1 Kits (3) and many more products for this protein.
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Human Polyclonal ZC3HC1 Primary Antibody for IHC, IHC (p) - ABIN4339759
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (show ALK Antibodies) (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2 (show MAPK1 Antibodies)).
Results reveal a novel role for NIPA in meiosis.
phosphorylated NIPA is degraded in late mitosis in an APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies))-dependent manner
NIPA has an antiapoptotic role in NPM (show NPM1 Antibodies)-ALK (show ALK Antibodies)-mediated signaling events
This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA.
ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort.
Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis.
The NIPA protein is a human F-box-containing protein that defines an SCF (show KITLG Antibodies)-type E3 ligase (SCF (show KITLG Antibodies)(NIPA)) controlling mitotic entry.
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity).
, nuclear interacting partner of ALK
, nuclear interacting partner of anaplastic lymphoma kinase (Alk)
, nuclear-interacting partner of ALK
, nuclear-interacting partner of anaplastic lymphoma kinase
, zinc finger C3HC-type protein 1
, hematopoietic stem/progenitor cell protein 216
, nuclear interacting partner of anaplastic lymphoma kinase (ALK)
, zinc finger, C3HC-type 1