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Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. Additionally we are shipping and many more products for this protein.
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Human Polyclonal ZDHHC21 Primary Antibody for FACS, IHC (p) - ABIN651365
Mill, Lee, Fukata, Tsutsumi, Fukata, Keighren, Porter, McKie, Smyth, Jackson: Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. in PLoS genetics 2009
Show all 3 references for ABIN651365
ZDHHC21 F233Delta diminishes the function of vascular alpha1 adrenergic receptors, leading to reduced vascular tone, which manifests in vivo as hypotension and tachycardia.
the Src (show SRC Antibodies)-family kinase, Fyn (show FYN Antibodies), involved in keratinocyte differentiation, is a direct palmitoylation target of Zdhhc21 and is mislocalized in mutant follicles
We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 (show PECAM1 Antibodies) at the cell surface.
the DHHC-7 (show ZDHHC7 Antibodies) and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor (show ESR2 Antibodies) localization and function
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).
probable palmitoyltransferase ZDHHC21
, zinc finger, DHHC-type containing 21
, zinc finger, DHHC domain containing 21
, zinc finger DHHC domain-containing protein 21
, GABA-A receptor-associated membrane protein 3
, palmitoyltransferase ZDHHC21