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Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Additionally we are shipping Zinc Finger, DHHC-Type Containing 17 Antibodies (45) and many more products for this protein.
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These data suggest that HIP14 is essential for maintenance of life and neuronal integrity in the adult mouse.
The findings of this study identify ZDHHC17 as an important upstream factor of ERK1/2 to regulate the interaction between TrkA (show NTRK1 Proteins) and tubulin (show TUBB Proteins) during neuronal development.
Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 (show ZDHHC13 Proteins) recognize peptide sequence in several unrelated proteins.
Loss of Hip14 and Hip14l (show ZDHHC13 Proteins) leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.
Data indicate that thioesterases APT1 (show FAS Proteins)/APT2 (show TAP2 Proteins) depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2 (show NMNAT2 Proteins)) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2 (show NMNAT2 Proteins).
In the absence of HIP14, striatal neurons become dysfunctional, leading to impaired motor behavior.
The constitutive absence of Hip14/DHHC17 results in major neurophysiological deficits and associated cognitive dysfunction.
altered palmitoylation mediated by HIP14 may contribute to HD.
Wild-type HTT (show HTT Proteins) modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Immunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin (show INS Proteins)-positive cells in islets of Langerhans.
The large number of zDABM sequences within the human proteome suggests that zDHHC17 may be an interaction hub regulating many cellular processes.
CPj0783 might cause abnormal vesicle-mediated transport by interacting with HIP14.
This suggests that altered HIP14-HTT (show HTT Proteins) and HIP14L (show ZDHHC13 Proteins)-HTT (show HTT Proteins) interactions in the presence of the HD mutation reduces palmitoylation and promotes mislocalization of HTT (show HTT Proteins) and other HIP14/HIP14L (show ZDHHC13 Proteins) substrates
Data show that deletion of huntingtin (show HTT Proteins) protein (HTT (show HTT Proteins)) amino acids 1-427 abolishes the interaction of HTT (show HTT Proteins) with palmitoyl acyltransferases huntingtin interacting protein 14 (HIP14) and huntingtin interacting protein 14-like (HIP14L (show ZDHHC13 Proteins)).
HIP14 shares a high proportion of interactors with HTT (show HTT Proteins) resulting in defective palmitoylation of the target proteins which might be an important mechanism towards pathogenesis of Huntington's disease.
DHHC17 is a ClipR-59 (show CLIP3 Proteins) palmitoyltransferase that modulates ClipR-59 (show CLIP3 Proteins) plasma membrane binding.
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.
Novel peptides have been developed that target the jun (show JUN Proteins) N-terminus kinase (JNK (show MAPK8 Proteins))-interacting motif on zD17 to selectively block enhancement of the zD17-Jun (show JUN Proteins) N terminus kinase (JNK (show MAPK8 Proteins)) interaction and the activation of JNK (show MAPK8 Proteins) isoforms 2 and 3.
a subset of DHHCs controls STREX palmitoylation and function; DHHC17 may preferentially target cysteine-rich domains
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport (By similarity).
zinc finger, DHHC-type containing 17
, huntingtin interacting protein 14
, palmitoyltransferase ZDHHC17-like
, huntingtin-interacting protein 14
, palmitoyltransferase ZDHHC17
, zinc finger DHHC domain-containing protein 17
, Huntingtin interacting protein H
, huntingtin interacting protein 3
, huntingtin yeast partner H
, huntingtin-interacting protein 3
, huntingtin-interacting protein H
, putative MAPK-activating protein PM11
, putative NF-kappa-B-activating protein 205
, zinc finger, DHHC domain containing 17
, membrane-associated DHHC17 zinc finger protein