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ZNF384 encodes a C2H2-type zinc finger protein, which may function as a transcription factor. Additionally we are shipping Zinc Finger Protein 384 Antibodies (54) and many more products for this protein.
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Rare translocation t(12;17)(p13;q12), This translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15 (show TAF15 Proteins)-ZNF384 fusion gene, in only six cases.
The transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 (show EWSR1 Proteins) or TAF15 (show TAF15 Proteins).
The CIZ protein(also known as ZNF384)was involved and rearrangemented in acute leukemia.
These results suggest that caspase (show CASP3 Proteins)-mediated degradation may represent a novel regulatory mechanism that controls TAF15 (show TAF15 Proteins) and TAF15 (show TAF15 Proteins)-CIZ/NMP4 activities.
Nmp4/CIZ limits the parathyroid hormone (show PTH Proteins) anabolic window by restricting the number of bone marrow stem, progenitor, and blood cells that support anabolic bone remodeling.
The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells.
Together these results provide experimental support for the concept that Nmp4/CIZ plays an inhibitory role in the response of bone cells to mechanical stimulation induced by OFSS.
Nmp4/CIZ within the context of the PTH (show PTH Proteins)-induced anabolic response is described.
Impaired spermatogenesis and male infertility occurred in Nmp4-disrupted mice.
transformation of 3T3 fibroblasts by CIZ/NMP4 fusions is dependent on DNA-binding and might involve transactivation of CIZ target genes
Two adjacent promoters of Nmp4 P(1) [-2521 nucleotide (nt)/-597 nt] and P(2) (-2521 nt/+1 nt) initiate transcription of alternative first exons (U(1) and U(2)).
Histomorphometric analysis revealed that unloading suppressed the levels of osteoblastic bone formation parameters, and such suppression of bone formation parameters was blocked by CIZ-deficiency.
Nmp4 contributes to fluid shear stress induced MMP13 (show MMP13 Proteins) gene induction in osteoblasts.
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7.
CAG repeat protein 1
, Cas-interacting zinc finger protein
, expanded repeat domain, CAG/CTG 2
, nuclear matrix transcription factor 4
, trinucleotide repeat-containing gene 1 protein
, nuclear matrix protein 4
, Cas-associated zinc finger protein