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Zinc Finger Protein 703 Proteins (ZNF703)

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Additionally we are shipping Zinc Finger Protein 703 Antibodies (87) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZNF703 80139 Q9H7S9
Mouse ZNF703 ZNF703 353310 P0CL69
Rat ZNF703 ZNF703 680717  
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

ZNF703 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Zinc Finger Protein 703 (ZNF703) Interaction Partners

Human Zinc Finger Protein 703 (ZNF703) interaction partners

  1. Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm.

  2. ZNF703 was a target of SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins).

  3. Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC (show CALR Proteins)) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene (show RAB1A Proteins) in CRC (show CALR Proteins).

  4. The results showed that ZNF703 acts as a gastric cancer oncogene (show RAB1A Proteins)

  5. High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.

  6. Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway, downregulated ERalpha (show ESR1 Proteins), and reduced the antitumor effect of tamoxifen.

  7. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.

  8. ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells.

  9. These data strongly point to ZNF703 as a novel oncogene (show RAB1A Proteins) in Luminal B breast cancer.

  10. Data show that FGFR1 (show FGFR1 Proteins) and DDHD2 (show DDHD2 Proteins) at 8p12 cooperated functionally with MYC (show MYC Proteins), whereas CCND1 (show CCND1 Proteins) and ZNF703 cooperated with a dominant negative form of TP53 (show TP53 Proteins).

Mouse (Murine) Zinc Finger Protein 703 (ZNF703) interaction partners

  1. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.

  2. Zeppo1 is a key regulator of breast cancer progression

Zebrafish Zinc Finger Protein 703 (ZNF703) interaction partners

  1. Nlz1 is required for cilia formation in zebrafish embryogenesis.

  2. nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 (show ZNF503 Proteins) is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon.

  3. Nlz1/Znf703 acts as a repressor of transcription

  4. identify misregulation of pax2 (show PAX2 Proteins) in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 (show ZNF503 Proteins) act upstream of the Pax2 (show PAX2 Proteins) pathway in directing proper closure of the optic fissure

Zinc Finger Protein 703 (ZNF703) Protein Profile

Protein Summary

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.

Gene names and symbols associated with ZNF703

  • zinc finger protein 703 (ZNF703)
  • zinc finger protein 703 (Zfp703)
  • zinc finger protein 703 (znf703)
  • 1110032O19Rik protein
  • AI430822 protein
  • AL022941 protein
  • cb514 protein
  • Csmn1 protein
  • End2 protein
  • fc45d06 protein
  • fk28e09 protein
  • NH11 protein
  • nlz protein
  • nlz1 protein
  • noz1 protein
  • wu:fc45d06 protein
  • wu:fk28e09 protein
  • Zeppo1 protein
  • zgc:111927 protein
  • ZNF503L protein
  • Znf703 protein
  • Zpo1 protein

Protein level used designations for ZNF703

zinc finger elbow-related proline domain protein 1 , ES neuronal differentiation 2 , nocA related zinc finger 1 , nocA-like zinc finger protein 1 , nocA-related zinc finger protein 1

GENE ID SPECIES
770560 Gallus gallus
80139 Homo sapiens
482855 Canis lupus familiaris
100525011 Sus scrofa
782419 Bos taurus
353310 Mus musculus
680717 Rattus norvegicus
114429 Danio rerio
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