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ZFAT encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. Additionally we are shipping and many more products for this protein.
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The present study observed, for the first time, that in an Arabian Gulf population, the ZFAT rs733254 polymorphism (T>G) is a genderspecific risk marker for multiple sclerosis.
We describe the structural features of the ZFAT ZFs, including the structural differences on the putative DNA recognition surfaces among the ZFAT ZFs, and the unique interaction mode within the tandem ZFs of ZF4 and ZF5 (show ZFP161 Antibodies)
ZFAT is paternally expressed in the placenta (as ZFAT-AS1, a non-coding antisense RNA)but biallelic in other tissues.
ZFAT polymorphism was associated with the Hashimoto disease severity but not with its development.
These results suggest that ZFAT may have critical roles in the capillary-like network formation that is involved in vascular remodeling.
It plays a specific role in differentiation and immunologic stimulation in B and T cells to cause autoimmune thyroid disease and contains AT-hook domain and 18 C2H2-type zin (show STRN4 Antibodies) finger domain.
Polymorphism, Single Nucleotide in ZFAT is associated with autoimmune thyroid disease
ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells
findings demonstrated that Zfat regulates the transcription of target genes by binding directly to the TSS (show RPL38 Antibodies) proximal region, and that Zfat-target genes play important roles in T-cell homeostasis
Zfat-deficient T cells show increased numbers of autophagosomes and decreased levels of p62 (show GTF2H1 Antibodies) protein, together indicating that Zfat deficiency promotes lysosomal FoxO1 (show FOXO1 Antibodies) degradation through autophagy.
results demonstrate that Zfat critically participates in the development of DP thymocytes through regulating the activities of p38 (show CRK Antibodies) and JNK (show MAPK8 Antibodies).
Zfat is required for peripheral T-cell homeostasis through IL-7Ralpha (show IL7R Antibodies) expression by controlling the FoxO1 (show FOXO1 Antibodies) protein.
Zfat-deficiency results in a loss of CD3zeta (show CD247 Antibodies) phosphorylation with dysregulation of ERK (show EPHB2 Antibodies) and Egr (show EGR1 Antibodies) activities leading to impaired positive selection.
ZFAT is a critical molecule for cell survival in MEFs and MOLT-4 cells at least in part through the regulation of the apoptosis involved in the BCL-2- and IL6st-mediated pathways.
ZFAT is indispensable for mouse embryonic development and functions as a critical transcription factor for primitive hematopoiesis through direct-regulation of Tal1 (show TAL1 Antibodies), Lmo2 (show LMO2 Antibodies), and Gata1 (show GATA1 Antibodies)
Study shows that ZFAT protein is expressed in B and T lymphocytes in mouse and that ZFAT regulates immune-related genes functionally important for immune responsiveness.
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
zinc finger and AT hook domain containing
, zinc finger protein 406-like
, zinc finger protein ZFAT-like
, zinc finger gene in autoimmune thyroid disease
, zinc finger protein 406
, zinc finger protein ZFAT
, zinc-finger gene in AITD susceptibility region
, ZFAT zinc finger 1
, zinc finger protein 403