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May be involved in transcriptional regulation.. Additionally we are shipping and many more products for this protein.
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Human Polyclonal ZBTB4 Primary Antibody for EIA, WB - ABIN783355
Yamada, Pérez-Torrado, Filion, Caly, Jammart, Devignot, Sasai, Ravassard, Mallet, Sastre-Garau, Schmitz, Defossez: The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. in Oncogene 2009
Show all 4 references for ABIN783355
Human Polyclonal ZBTB4 Primary Antibody for EIA, IHC (fro) - ABIN1109539
Weber, Marquardt, Elzi, Forster, Starke, Glaum, Yamada, Defossez, Delrow, Eisenman, Christiansen, Eilers: Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation. in The EMBO journal 2008
Show all 2 references for ABIN1109539
Thus, EZH2 (show EZH2 Antibodies) is reciprocally regulated by a novel signaling network consisting of Sp proteins, oncogenic miRs and ZBTB4, and modulation of this gene network is a novel therapeutic approach for treatment of breast cancer and possibly other cancers.
ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival
the human zinc-finger protein ZBTB4 binds methylated DNA in a sequence-specific manner.
ZBTB4 binds methylated methylated CpGs in vitro and in vivo and represses transcrption.
These data suggest that Zbtb4 is a critical determinant of the cellular response to p53 (show TP53 Antibodies) activation and reinforce the notion that p21Cip1 (show CDKN1A Antibodies) can provide an essential survival signal in cells with activated p53 (show TP53 Antibodies).
Results show that overexpressing HIPK2 (show HIPK2 Antibodies) causes the degradation of ZBTB4, whereas overexpressing a kinase-deficient mutant of HIPK2 (show HIPK2 Antibodies) has no effect.
May be involved in transcriptional regulation.
KAISO-like zinc finger protein 1
, zinc finger and BTB domain-containing protein 4