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Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. Additionally we are shipping alpha 2 Macroglobulin Antibodies (235) and alpha 2 Macroglobulin Kits (66) and many more products for this protein.
Showing 10 out of 43 products:
Human alpha 2 Macroglobulin Protein expressed in Human - ABIN491569
Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013
Human alpha 2 Macroglobulin Protein expressed in Baculovirus infected Insect Cells - ABIN2003651
Coutinho, Cavalcanti, van Leuven, Araújo-Jorge: Alpha-2-macroglobulin binds to the surface of Trypanosoma cruzi. in Parasitology research 1997
This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 Proteins) acts as an upstream regulator of the PDK1 (show PDK1 Proteins)/PLK1 signaling axis to modulate c-MYC (show MYC Proteins) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Proteins)-associated malignant progression.
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.
These data demonstrate that alpha2M* and LRP1 (show LRP1 Proteins) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 Proteins)+)dynamics in hMSMCs during pregnancy.
we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins
A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2 (show MMP2 Proteins)/9 activity by several mechanisms including the up-regulation of A2M.
Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland.
A2M is not the only biological candidate gene for AD determination
Alpha2M causes neurodegeneration in a p75(NTR (show NGFR Proteins))- and proNGF-dependent manner.
there is no enough evidence for associations of A2M gene polymorphisms (5 bp I/D, Ile1000Val) with Alzheimer's disease risk
phosphorylating the T-loop Akt (show AKT1 Proteins) residue Thr (show TRH Proteins)(308) by PDK1 (show PDK1 Proteins) requires Raptor (show RPTOR Proteins) of the mTORC1 complex as a platform or scaffold protein (show HOMER1 Proteins).
Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.
We report here for the first time the direct isolation of Spp24 (show SPP2 Proteins) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 Proteins)-alpha2M) from bovine calf serum.
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.
These results suggest the possible involvement of cathepsin E (show CTSE Proteins) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5 (show ADAMTS5 Proteins)
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Proteins) remains labile and available to down-regulate Fpn1 (show SLC40A1 Proteins).
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.
MMP9 (show MMP9 Proteins) production promoted by the alpha(2)M*/LRP1 (show LRP1 Proteins) interaction required the activation of both MAPK (show MAPK1 Proteins)-ERK1/2 and NF-kappaB (show NFKB1 Proteins) signaling pathways.
Alpha2 macroglobulin requires cyclic amp (show TMPRSS5 Proteins) and signal transduction for cell growth
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents
Data describe the role of the PI3-kinase (show PIK3CA Proteins)/PDK (show PDK2 Proteins)/Akt (show AKT1 Proteins)/p70s6k (show RPS6KB1 Proteins) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 Proteins) in these events.
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind
PDGF (show PDGFA Proteins)-BB and TGF-beta1 (show TGFB1 Proteins) binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit
Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
, ovomacroglobulin, ovostatin
, alpha 2m
, alpha-2-macroglobulin b
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
, pregnancy zone protein