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Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. Additionally we are shipping alpha 2 Macroglobulin Antibodies (303) and alpha 2 Macroglobulin Kits (92) and many more products for this protein.
Showing 10 out of 40 products:
Human alpha 2 Macroglobulin Protein expressed in Human - ABIN3119641
Ksiazek, Mizgalska, Enghild, Scavenius, Thogersen, Potempa: Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. in The Journal of biological chemistry 2015
Human alpha 2 Macroglobulin Protein expressed in Human - ABIN935646
Rahman, Jeng, Singh, Coughlin, Essani, McFadden: Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L. in Virology 2009
Human alpha 2 Macroglobulin Protein expressed in Human - ABIN491569
Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013
The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3 (show STAT3 Proteins), may be an important protein in the pathogenesis of allergic rhinitis in AR patients.
Proteomics study showed a strong association of FN1 (show FN1 Proteins), A2M, C4BPA (show C4BPA Proteins) and CFB (show CFB Proteins) in molecular subtypes of breast cancer, in which, C4BPA (show C4BPA Proteins) and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB (show HLA-DPB1 Proteins)) and Triple-negative (TN)subtypes in BC patients, respectively.
BBB disruption is present in ACS (show PLA2G15 Proteins), and elevated levels of IL-6 (show IL6 Proteins) and C3 in CSF (show CSF2 Proteins) in diffuse NPSLE
Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.
The plasma level of alpha2M was found positively correlated, while HCII (show SERPIND1 Proteins) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (show SERPIND1 Proteins) may be potential biomarkers for evaluation of the vulnerability of carotid ...
Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.
Data show that low that low globulin (GLB (show DCXR Proteins)) levels were significantly associated with favorable survival, and low ALB (show ALB Proteins) levels were associated with a significantly worse survival .
This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 Proteins) acts as an upstream regulator of the PDK1 (show PDK1 Proteins)/PLK1 signaling axis to modulate c-MYC (show MYC Proteins) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Proteins)-associated malignant progression.
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.
These data demonstrate that alpha2M* and LRP1 (show LRP1 Proteins) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 Proteins)+)dynamics in hMSMCs during pregnancy.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 Proteins)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Proteins) remains labile and available to down-regulate Fpn1 (show SLC40A1 Proteins).
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.
MMP9 (show MMP9 Proteins) production promoted by the alpha(2)M*/LRP1 (show LRP1 Proteins) interaction required the activation of both MAPK (show MAPK1 Proteins)-ERK1/2 and NF-kappaB (show NFKB1 Proteins) signaling pathways.
Alpha2 macroglobulin requires cyclic amp (show TMPRSS5 Proteins) and signal transduction for cell growth
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents
Data describe the role of the PI3-kinase (show PIK3CA Proteins)/PDK (show PDK2 Proteins)/Akt (show AKT1 Proteins)/p70s6k (show RPS6KB1 Proteins) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 Proteins) in these events.
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind
Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.
Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.
We report here for the first time the direct isolation of Spp24 (show SPP2 Proteins) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 Proteins)-alpha2M) from bovine calf serum.
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.
These results suggest the possible involvement of cathepsin E (show CTSE Proteins) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5 (show ADAMTS5 Proteins)
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
, ovomacroglobulin, ovostatin
, alpha 2m
, alpha-2-macroglobulin b
, pregnancy zone protein