alpha-2-Macroglobulin Proteins (A2M)

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. Additionally we are shipping alpha 2 Macroglobulin Antibodies (303) and alpha 2 Macroglobulin Kits (92) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
A2M 2 P01023
A2M 24153 P06238
A2M 232345 Q6GQT1
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Top alpha 2 Macroglobulin Proteins at

Showing 10 out of 40 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 15 to 18 Days
Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 20 to 21 Days
Human Human Un-conjugated 5 mg Log in to see 2 to 3 Days
Human Human Un-conjugated 1 mg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

A2M Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Rat (Rattus) ,

Mouse (Murine) ,

Top referenced alpha 2 Macroglobulin Proteins

  1. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN3119641 : Ksiazek, Mizgalska, Enghild, Scavenius, Thogersen, Potempa: Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. in The Journal of biological chemistry 2015 (PubMed)

  2. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN935646 : Rahman, Jeng, Singh, Coughlin, Essani, McFadden: Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L. in Virology 2009 (PubMed)

  3. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN491569 : Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013 (PubMed)

More Proteins for alpha-2-Macroglobulin (A2M) Interaction Partners

Human alpha-2-Macroglobulin (A2M) interaction partners

  1. The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3 (show STAT3 Proteins), may be an important protein in the pathogenesis of allergic rhinitis in AR patients.

  2. Proteomics study showed a strong association of FN1 (show FN1 Proteins), A2M, C4BPA (show C4BPA Proteins) and CFB (show CFB Proteins) in molecular subtypes of breast cancer, in which, C4BPA (show C4BPA Proteins) and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB (show HLA-DPB1 Proteins)) and Triple-negative (TN)subtypes in BC patients, respectively.

  3. BBB disruption is present in ACS (show PLA2G15 Proteins), and elevated levels of IL-6 (show IL6 Proteins) and C3 in CSF (show CSF2 Proteins) in diffuse NPSLE

  4. Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.

  5. The plasma level of alpha2M was found positively correlated, while HCII (show SERPIND1 Proteins) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (show SERPIND1 Proteins) may be potential biomarkers for evaluation of the vulnerability of carotid ...

  6. Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.

  7. Data show that low that low globulin (GLB (show DCXR Proteins)) levels were significantly associated with favorable survival, and low ALB (show ALB Proteins) levels were associated with a significantly worse survival .

  8. This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 Proteins) acts as an upstream regulator of the PDK1 (show PDK1 Proteins)/PLK1 signaling axis to modulate c-MYC (show MYC Proteins) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Proteins)-associated malignant progression.

  9. Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.

  10. These data demonstrate that alpha2M* and LRP1 (show LRP1 Proteins) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 Proteins)+)dynamics in hMSMCs during pregnancy.

Mouse (Murine) alpha-2-Macroglobulin (A2M) interaction partners

  1. To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 Proteins)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice

  2. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Proteins) remains labile and available to down-regulate Fpn1 (show SLC40A1 Proteins).

  3. Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.

  4. MMP9 (show MMP9 Proteins) production promoted by the alpha(2)M*/LRP1 (show LRP1 Proteins) interaction required the activation of both MAPK (show MAPK1 Proteins)-ERK1/2 and NF-kappaB (show NFKB1 Proteins) signaling pathways.

  5. Alpha2 macroglobulin requires cyclic amp (show TMPRSS5 Proteins) and signal transduction for cell growth

  6. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

  7. the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents

  8. Data describe the role of the PI3-kinase (show PIK3CA Proteins)/PDK (show PDK2 Proteins)/Akt (show AKT1 Proteins)/p70s6k (show RPS6KB1 Proteins) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 Proteins) in these events.

  9. review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.

  10. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind

Pig (Porcine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.

Cow (Bovine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.

  2. We report here for the first time the direct isolation of Spp24 (show SPP2 Proteins) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 Proteins)-alpha2M) from bovine calf serum.

  3. Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.

  4. These results suggest the possible involvement of cathepsin E (show CTSE Proteins) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.

  5. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5 (show ADAMTS5 Proteins)

  6. Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.

alpha 2 Macroglobulin (A2M) Protein Profile

Protein Summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Gene names and symbols associated with alpha-2-Macroglobulin Proteins (A2M)

  • alpha-2-macroglobulin (A2M)
  • alpha-2-macroglobulin (A2m)
  • alpha-2-macroglobulin (LOC477699)
  • pregnancy-zone protein L homeolog (pzp.L)
  • alpha-2-macroglobulin (AZL_c00450)
  • ovostatin-like (LOC100224071)
  • alpha-2-macroglobulin (LOC100349077)
  • ovostatin (OVST)
  • alpha-2-macroglobulin (a2m)
  • alpha-2-macroglobulin (LOC100061656)
  • alpha-2-macroglobulin (LOC100090399)
  • alpha-2-macroglobulin S homeolog (a2m.S)
  • alpha-2-macroglobulin (LOC100469973)
  • alpha-2-macroglobulin (LOC100595735)
  • pregnancy zone protein (PZP)
  • alpha-2-macroglobulin (LOC100353095)
  • alpha-2-macroglobulin (LOC101122940)
  • alpha-2-macroglobulin (LOC101801552)
  • alpha-2-macroglobulin-like (LOC100911545)
  • A2M protein
  • A2m1 protein
  • A2maa protein
  • A2MAC1 protein
  • a2mb protein
  • A2MD protein
  • A2mp protein
  • Alpha-2-M protein
  • cpamd5 protein
  • endod protein
  • endodermin protein
  • fwp007 protein
  • LOC733429 protein
  • LOC100224071 protein
  • Mam protein
  • s863-7 protein

Protein level used designations for alpha-2-Macroglobulin Proteins (A2M)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 , alpha-2-M , alpha-2-macroglobulin-P , alpha-2-macroglobulin , alpha-2-macroglobulin-like , ovomacroglobulin, ovostatin , alpha 2m , endodermin , Alpha2-macroglobulin , alpha-2-macroglobulin b , pregnancy zone protein

2 Homo sapiens
24153 Rattus norvegicus
232345 Mus musculus
403166 Sus scrofa
418251 Gallus gallus
465372 Pan troglodytes
477699 Canis lupus familiaris
513856 Bos taurus
716834 Macaca mulatta
733429 Xenopus laevis
8794592 Azospirillum sp. B510
100173946 Pongo abelii
100224071 Taeniopygia guttata
100349077 Oryctolagus cuniculus
100390764 Callithrix jacchus
396151 Gallus gallus
619586 Xenopus (Silurana) tropicalis
100061656 Equus caballus
100090399 Ornithorhynchus anatinus
100158443 Xenopus laevis
100469973 Ailuropoda melanoleuca
100595735 Nomascus leucogenys
100153288 Sus scrofa
100353095 Oryctolagus cuniculus
101122940 Ovis aries
101801552 Anas platyrhynchos
100911545 Rattus norvegicus
101794357 Anas platyrhynchos
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