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beta-Site APP-Cleaving Enzyme 1 Proteins (BACE)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Antibodies (204) and beta-Site APP-Cleaving Enzyme 1 Kits (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top beta-Site APP-Cleaving Enzyme 1 Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 200 μg Log in to see 2 to 3 Days
$253.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$756.00
Details
Insect Cells Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$651.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$771.10
Details

BACE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, ,
Rat (Rattus) ,

Human , , , , , , ,
, , , ,

Top referenced beta-Site APP-Cleaving Enzyme 1 Proteins

  1. Human BACE Protein expressed in Human Cells - ABIN2002001 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 5 references for ABIN2002001

  2. Mouse (Murine) BACE Protein expressed in Human Cells - ABIN2007129 : Yan, Bienkowski, Shuck, Miao, Tory, Pauley, Brashier, Stratman, Mathews, Buhl, Carter, Tomasselli, Parodi, Heinrikson, Gurney: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. in Nature 1999 (PubMed)
    Show all 5 references for ABIN2007129

  3. Human BACE Protein expressed in HEK-293 Cells - ABIN2180628 : Willem, Garratt, Novak, Citron, Kaufmann, Rittger, DeStrooper, Saftig, Birchmeier, Haass: Control of peripheral nerve myelination by the beta-secretase BACE1. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for ABIN2180628

More Proteins for beta-Site APP-Cleaving Enzyme 1 (BACE) Interaction Partners

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. The electrophysiological effects of BACE1 on KCNQ1 (show KCNQ1 Proteins) reported here were independent of its enzymatic activity.

  2. Results suggest that ubiquilin-1 (show UBQLN1 Proteins) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  3. Results indicate that DISC (show DISC1 Proteins)1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysoso (show APP Proteins)mal degradation of BACE1

  4. A single bout of exercise reduced BACE1 cortical content and activity in obese mice.

  5. reduction in miR (show MLXIP Proteins)-186 levels during aging may lead to the up-regulation of BACE1 in the brain, thereby increasing a risk for Alzheimer's disease

  6. reveal Dicer1 (show DICER1 Proteins)-miR (show MLXIP Proteins)-328-Bace1 signalling as a determinant of brown adipose tissue function

  7. The present findings are consistent with our previous behavioral data showing that BACE1 haploinsufficiency rescues memory deficits in 5XFAD mice irrespective of sex but only in the younger age group.

  8. p38alpha (show MAPK14 Proteins) MAPK (show MAPK1 Proteins) plays a critical role in the regulation of BACE1 degradation and Abeta (show APP Proteins) generation in Alzheimer Disease pathogenesis

  9. Swedish mutant APP (show APP Proteins)-based BACE1 binding site peptide reduces APP (show APP Proteins) beta-cleavage and cerebral Abeta (show APP Proteins) levels in Alzheimer's mice.

  10. evidence that HFD, by regulation of subcellular trafficking of BACE1, promotes APP (show APP Proteins) cleavage.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results suggest that ubiquilin-1 (show UBQLN1 Proteins) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  2. Results suggest that DISC1 (show DISC1 Proteins) interacts with BACE1 and promotes lysosomal degradation of BACE1, thus reducing the generation of Abeta (show APP Proteins)

  3. GG genotype and G allele of BACE1 gene rs638405 probably increase the risk of AD. [META-ANALYSIS]

  4. study reports that sAbetaPPalpha, the product of the cleavage of AbetaPP by alpha-secretase, is a potent endogenous direct inhibitor of the BACE enzyme, and that its inhibition is likely by an allosteric mechanism

  5. p38alpha (show MAPK14 Proteins) MAPK (show MAPK1 Proteins) plays a critical role in the regulation of BACE1 degradation and Abeta (show APP Proteins) generation in Alzheimer Disease pathogenesis

  6. this is the first study to acquire a DNA aptamer that exhibited binding specificity to BACE1 and inhibited its activity.

  7. Results reveal a link between p25 (show LCN2 Proteins) and BACE1 in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 Proteins) activation by p25 (show LCN2 Proteins) accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation.

  8. the Alzheimer's disease-protective 'Icelandic' mutation greatly attenuates APP (show APP Proteins)-BACE-1 interactions, suggesting a mechanistic basis for protection.

  9. Studies suggest that beta-Secretases BACE1/2 plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.

  10. analysis of the differential dose-dependent effects of simvastatin on HIF-1alpha (show HIF1A Proteins) and BACE in cultured Alzheimer's disease cybrid cells

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Proteins) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Protein Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1)
  • beta-site APP-cleaving enzyme 1 (MGC145931)
  • beta-site APP-cleaving enzyme 1 (LOC100232107)
  • beta-site APP-cleaving enzyme 2 (bace2)
  • beta-site APP-cleaving enzyme 2 (BACE2)
  • beta-site APP-cleaving enzyme 2 (LOC100224177)
  • beta-site APP cleaving enzyme 1 (Bace1)
  • beta-site APP-cleaving enzyme 1 (bace1)
  • ASP2 protein
  • BACE protein
  • BACE1 protein
  • BACE2 protein
  • C76936 protein
  • HSPC104 protein
  • MGC68482 protein
  • MGC68881 protein
  • MGC145931 protein
  • zgc:77409 protein

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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