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DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. Additionally we are shipping DLK1 Antibodies (118) and DLK1 Kits (11) and many more products for this protein.
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DLK1 mRNA expression in mesenteric fat was higher than subcutaneous fat. DLK1 mRNA expression in Holstein cattle mesenteric fat was higher than Wagyu cattle.
The four loci of DLK1 gene and CLPG gene in 1109 individuals, which belong to eight breeds/species of bovidae, including cattle, buffalo and yak, were analyzed.
tissue-specific expression patterns of Dlk-1 splice variants in bovine tissues
Results suggest a potential signalling hierarchy between Delta-like 1 (show DLL1 Proteins) and ephrin-B2 (show EFNB2 Proteins) ligands, as neural stem cells adopt the Delta-like 1 (show DLL1 Proteins) phenotype of stem cell maintenance on simultaneous presentation of both signals.
The results indicate the occurrence of epimutation affecting the IG-DMR (show WDR20 Proteins) and the MEG3 (show FAM129B Proteins)-DMR (show WDR20 Proteins) in the two cases, and imply that UPD (show UROD Proteins)(14)mat and related (epi (show TFPI Proteins))genetic aberrations constitute a rare but important underlying factor for Silver-Russell Syndrome
Kaplan-Meier analysis indicated that higher DLK1 levels were associated with shorter survival in Hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. These results suggest that the serum levels of DLK1 may serve as a prognostic biomarker for HCC (show FAM126A Proteins) patients.
Notch (show NOTCH1 Proteins) pathway activation in endothelial colony forming cells in vivo via co-implanted stromal cells expressing delta-like 1 (show DLL1 Proteins) promotes vasculogenesis.
Data show that the median expression of Jagged-1 (show JAG1 Proteins) protein and delta-like 1 (show DLL1 Proteins) protein (Dll-1 (show DLL1 Proteins)) was significantly higher in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) blasts than in peripheral blood stem cells (PBSCs).
DLK1 expression diminishes during differentiation of human U937 cel (show NOTCH1 Proteins)ls to macrophages.
Data show that preadipocyte factor 1 Pref-1 is probably not a major contributor to gestational diabetes mellitus (GDM) pathophysiology but might directly contribute to triglycerides (TG) metabolism, as well as depend on gestational age and renal function.
These mice show improved glucose tolerance. Taken together, we conclude Pref-1 as a positive regulator of islet beta-cells and insulin (show INS Proteins) production.
Serum levels of Pref-1 were associated with the amount of alcohol consumed during the past 30 days.
DLK1 can promote the invasion of lung cancer cells by upregulating MMP9 (show MMP9 Proteins) expression, which depends on Notch (show NOTCH1 Proteins) signaling
We did not observe significantly different expression of DLK1, MEG3 or PEG11 mRNA in any of analyzed breeds.
QUASEP supports paternal expression of DLK1 in whole brain, carcass, liver and placental tissues of day 30 interbreed porcine fetuses.
the sequence of porcine DLK1 (pDLK1)was examined,the expression and alternative splicing isoforms in the pig (Sus scrofa) was compared with human
Polymorphisms, imprinting status and quantitative trait locus analyses of the porcine DLK1 and MEG3 genes i swine.
Expression of DLK1 splice variants during adipocyte development in vitro and in vivo.
DNA methylation (show HELLS Proteins) regulates genomic imprinted DLK1-Dio3 (show DIO3 Proteins) miRNAs in autoimmune lupus
identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1-Dio3 (show DIO3 Proteins) locus
Dppa3 (show DPPA3 Proteins) has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Proteins) cells and maintenance of Dlk1-Dio3 (show DIO3 Proteins) imprinting
results suggest that maternal expression of the imprinted miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-544 cluster regulates paternal expression of the Dlk1 gene in mice
Dll1 (show DLL1 Proteins) and Jag1 (show JAG1 Proteins), Notch (show NOTCH1 Proteins) ligands, function redundantly and are necessary to maintain the centroacinar cells as an environmental niche in the developing pancreas.
Gtl2((-/+)) teratomas have decreased expression of 28 miRNAs encoded by the Dlk1-Dio3 (show DIO3 Proteins) domain
DLK1 is a novel inflammatory inhibitor which interferes with NOTCH1 (show NOTCH1 Proteins) signaling in TLR-activated murine macrophages.
Undercarboxylated osteocalcin (show BGLAP Proteins) (Glu (show GCG Proteins)-OCN) controlled production of DLK1 by pancreatic beta-cells acts as a negative feedback mechanism to counteract the stimulatory effects of insulin (show INS Proteins) on osteoblast production of Glu (show GCG Proteins)-OCN.
these data suggest that miR (show MLXIP Proteins)-143 promotes adipogenesis by directly modulating the pref-1 expression in adipocytes.
This study provides the spatiotemporal expression and dynamic changes of lncRNAs from Dlk1-Dio3 imprinted region in mouse preimplantation stage embryos and offers insight into the potential mechanisms responsible for Gtl2 activation.
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes\; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance\; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
, preadipocyte factor-1
, protein delta homolog 1
, delta-like 1 homolog (Drosophila)
, delta-like protein 1
, protein delta homolog 1-like
, fetal antigen 1
, preadipocyte factor 1
, adipocyte differentiation inhibitor protein
, stromal cell derived protein 1