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GGH catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. Additionally we are shipping gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase) Antibodies (80) and gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase) Kits (13) and many more products for this protein.
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Either methylation of CpG1 or hypermethylation of CpG2 in GGH promoter region can significantly reduce GGH mRNA expression in pediatric patients with acute leukemia.
the results of our study identify GGH as an ERG (show ERG Proteins) subtype specific molecular marker with modest prognostic relevance, which may have clinical relevance if analyzed in combination with other molecular markers.
These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors.
There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX (show MTX1 Proteins) treatment. CONCLUSIONS: The MTHFR (show MTHFR Proteins) 677CC and GGH 401TT and CT genotypes were associated with a reduction in the number of MTX (show MTX1 Proteins)-related adverse events.
the highest expression of GGH and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Proteins), FPGS (show FPGS Proteins), TOP1 (show TOP1 Proteins) and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP (show TYMP Proteins) expression was approximately equivalent in the right-sided colon and rectum
This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC (show ATIC Proteins) and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma
Polymorphism of GGH rs3758149 C>T is associated with response to therapy in acute lymphoblastic leukemia.
An interaction term, between FPGS (show FPGS Proteins) rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to metotrexate toxicity in rheumatoid arthritis.
GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in methotrexate treated rheumatoid arthritis patients.
Suggest that GGH may serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer.
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.
, gamma-glutamyl hydrolase
, folylpolyglutamate hydrolase
, gamma-Glu-x carboxypeptidase
, gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)