helicase 2, X-linked Proteins (ATRX)

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Antibodies (125) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATRX 546 P46100
ATRX 246284  
Mouse ATRX ATRX 22589 Q61687
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ATRX Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Macropus eugenii His tag   1 mg Log in to see 60 to 71 Days
$3,408.17
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,501.67
Details

ATRX Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for helicase 2, X-linked (ATRX) Interaction Partners

Human helicase 2, X-linked (ATRX) interaction partners

  1. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (show PARP1 Proteins) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  2. Distinct histological and molecular characteristics of adult diffuse gliomas with and without ATRX immunoreactivity indicate the utility of ATRX immunohistochemistry in diagnostic practice.

  3. ATRX loss can be reliable for the pathogenesis of neuroendocrine pancreatic neoplasms.

  4. Mutation in ATRX gene is associated with cancer more frequently in males.

  5. Nek1 (show NEK1 Proteins) phosphorylates Rad54 and regulates Rad51 (show RAD51 Proteins) removal to orchestrate homologous recombination and replication fork stability.

  6. Results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of RAD51 (show RAD51 Proteins) and RAD54 proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.

  7. ATRX interacts with ZNF274 (show ZNF274 Proteins), TRIM28 (show TRIM28 Proteins) and SETDB1 (show SETDB1 Proteins) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (show ZNF274 Proteins) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.

  8. somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome.

  9. AMab-6 sensitively detects ATRX in Western blot and immunohistochemical analyses, indicating that AMab-6 could become the standard marker to determine the ATRX mutation status of gliomas in immunohistochemical analyses

  10. our study describes a novel missense mutation of the ATRX gene helicase domain, carried by three affected males of the two generations of the same family and segregated with intellectual deficiency, dysmorphism and behaviour disorder without alpha-thalassaemia and with non-skewed X-chromosome inactivation

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (show PARP1 Proteins) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  2. Our study highlights the importance of the cooperation between Rad54 (show RAD54L Proteins) and Mus81 (show MUS81 Proteins) for mediating DNA DSB repair and restraining chromosome missegregation.

  3. The long noncoding RNA, TERRA (show DMRT2 Proteins) can bind both in cis (show CISH Proteins) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (show DMRT2 Proteins) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (show DMRT2 Proteins) activates, ATRX represses gene expression.

  4. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  5. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  6. Daxx (show DAXX Proteins) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS Proteins) levels are low.

  7. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  8. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

  9. ATRX promotes the incorporation of histone H3.3 (show H3F3A Proteins) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.

  10. Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (show CISH Proteins) along the X chromosome.

ATRX Protein Profile

Protein Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with helicase 2, X-linked Proteins (ATRX)

  • alpha thalassemia/mental retardation syndrome X-linked (ATRX)
  • alpha thalassemia/mental retardation syndrome X-linked (Atrx)
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx)
  • RAD54 like (S. cerevisiae) (Rad54l)
  • 4833408C14Rik protein
  • AI447451 protein
  • ATR2 protein
  • DXHXS6677E protein
  • HP1-BP38 protein
  • Hp1bp2 protein
  • Hp1bp38 protein
  • JMS protein
  • MRXHF1 protein
  • MRXS3 protein
  • Rad54 protein
  • RAD54L protein
  • SFM1 protein
  • SHS protein
  • XH2 protein
  • Xnp protein
  • ZNF-HX protein

Protein level used designations for helicase 2, X-linked Proteins (ATRX)

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
Selected quality suppliers for ATRX Proteins (ATRX)
Did you look for something else?